Molecular Mechanisms of Viral and Host Cell Substrate Recognition by Hepatitis C Virus NS3/4A Protease
about
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptorStructural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172Small molecule inhibitors of HCV replication from pomegranateHCV NS3 Blocking Effect on IFN Induced ISGs Like Viperin and IL28 With and Without NS4A.Structural analysis of asunaprevir resistance in HCV NS3/4A proteaseExpression of heterologous proteins flanked by NS3-4A cleavage sites within the hepatitis C virus polyprotein.Testing the substrate-envelope hypothesis with designed pairs of compounds.Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided DesignDirect-acting antiviral agents for hepatitis C: structural and mechanistic insights.Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.In-cell selectivity profiling of membrane-anchored and replicase-associated hepatitis C virus NS3-4A protease reveals a common, stringent substrate recognition profile.Prediction of substrate specificity in NS3/4A serine protease by biased sequence search threading.Methods: A small-molecule SMASh hit.The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.Molecular docking investigation of the binding interactions of macrocyclic inhibitors with HCV NS3 protease and its mutants (R155K, D168A and A156V).Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network analysis.Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism
P2860
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P2860
Molecular Mechanisms of Viral and Host Cell Substrate Recognition by Hepatitis C Virus NS3/4A Protease
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@ast
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@en
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@nl
type
label
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@ast
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@en
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@nl
prefLabel
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@ast
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@en
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@nl
P2093
P2860
P356
P1433
P1476
Molecular Mechanisms of Viral ...... atitis C Virus NS3/4A Protease
@en
P2093
Celia A Schiffer
Francesca Massi
Jennifer M Laine
Keith P Romano
Laura M Deveau
P2860
P304
P356
10.1128/JVI.00377-11
P577
2011-07-01T00:00:00Z