Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations - Test2 - elhamkhani - TriplyDB

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

http://www.wikidata.org/entity/Q27488616

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The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications Interferon Response in Hepatitis C Virus (HCV) Infection: Lessons from Cell Culture Systems of HCV Infection Animal models for the study of HCV New hepatitis C virus drug discovery strategies and model systems Innate immune responses in hepatitis C virus infection Production of infectious HCV genotype 1b virus in cell culture using a novel Set of adaptive mutations Assembly and release of infectious hepatitis C virus involving unusual organization of the secretory pathway Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase Increased susceptibility of Huh7 cells to HCV replication does not require mutations in RIG-I A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture Cell culture replication of a genotype 1b hepatitis C virus isolate cloned from a patient who underwent liver transplantation Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents Involvement of hepatitis C virus NS5A hyperphosphorylation mediated by casein kinase I-α in infectious virus production.Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies A new model to produce infectious hepatitis C virus without the replication requirement.Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.The rate of hepatitis C virus infection initiation in vitro is directly related to particle density.Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation.Hepatitis C virus experimental model systems and antiviral drug research.Bile acids specifically increase hepatitis C virus RNA-replication.The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus.Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.Potential treatment options and future research to increase hepatitis C virus treatment response rate Identification of a novel phosphorylation site in hepatitis C virus NS5A Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.Genetic complementation of hepatitis C virus nonstructural protein functions associated with replication exhibits requirements that differ from those for virion assembly.Isolation and characterization of highly replicable hepatitis C virus genotype 1a strain HCV-RMT Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4 Last stop before exit - hepatitis C assembly and release as antiviral drug targets.Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?The interaction between the hepatitis C proteins NS4B and NS5A is involved in viral replication Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1.The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

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Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

http://www.wikidata.org/entity/Q27488616

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2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Production of Infectious Genot ...... eplication Enhancing Mutations

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Gang Long

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George Koutsoudakis

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Margarita Zayas

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Nicole Appel

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Stephanie Kallis

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Thomas Pietschmann

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P2860

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B

Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes

Charged residues in the transmembrane domains of hepatitis C virus glycoproteins play a major role in the processing, subcellular localization, and assembly of these envelope proteins

Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.

Coupling between replication and packaging of flavivirus RNA: evidence derived from the use of DNA-based full-length cDNA clones of Kunjin virus

Robust hepatitis C virus infection in vitro.

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Ralf Bartenschlager

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Geert Leroux-Roels

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2009-06-01T00:00:00Z

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26287480

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