Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity - Test2 - elhamkhani - TriplyDB

Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity

Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity

http://www.wikidata.org/entity/Q27617593

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Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1 Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase.Human HTm4 is a hematopoietic cell cycle regulator CAK-independent activation of CDK6 by a viral cyclin Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene Biochemical characterization of Cdk2-Speedy/Ringo A2.Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors Structure and regulation of the human Nek2 centrosomal kinase The structure of CDK4/cyclin D3 has implications for models of CDK activation Discovery of a Potential Allosteric Ligand Binding Site in CDK2 Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis Crystal Structures of Human CaMKIα Reveal Insights into the Regulation Mechanism of CaMKI Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles Conformational changes in protein loops and helices induced by post-translational phosphorylation.Protein kinases: evolution of dynamic regulatory proteins Characterization of a new family of cyclin-dependent kinase activators.Kinetic basis for activation of CDK2/cyclin A by phosphorylation.Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2.Substrate and docking interactions in serine/threonine protein kinases An inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.Fast and automated functional classification with MED-SuMo: an application on purine-binding proteins.A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis Probing the role of nascent helicity in p27 function as a cell cycle regulator.Selectivity and potency of cyclin-dependent kinase inhibitors.Polyphony: superposition independent methods for ensemble-based drug discovery.Frequency response of a protein to local conformational perturbations.Cyclin-dependent protein kinases as therapeutic drug targets for antimalarial drug development.The biochemistry of mitosis Insights into the phosphoryl transfer mechanism of cyclin-dependent protein kinases from ab initio QM/MM free-energy studies.Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2 Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes.Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation.Targeting Conformational Activation of CDK2 Kinase.

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P2860

Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity

http://www.wikidata.org/entity/Q27617593

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1999 nî lūn-bûn

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1999 թուականի Մարտին հրատարակուած գիտական յօդուած

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1999 թվականի մարտին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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A M Lawrie

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G Divita

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J A Endicott

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L N Johnson

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M E Noble

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P2860

Cdk-activating kinase complex is a component of human transcription factor TFIIH

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Structural basis of cyclin-dependent kinase activation by phosphorylation

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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274

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10085115

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phosphorylation