Structure and regulation of the human Nek2 centrosomal kinase - Test2 - elhamkhani - TriplyDB

Structure and regulation of the human Nek2 centrosomal kinase

Structure and regulation of the human Nek2 centrosomal kinase

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Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase Mitotic regulation by NIMA-related kinases Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases Insights into the Conformational Variability and Regulation of Human Nek2 Kinase An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9 Crystal Structures of Human CaMKIα Reveal Insights into the Regulation Mechanism of CaMKI Substrate recognition of anthrax lethal factor examined by combinatorial and pre-steady-state kinetic approaches A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant Phylogenetic analysis of the Neks reveals early diversification of ciliary-cell cycle kinases."Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain.NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.Yet another "active" pseudokinase, Erb3 Role of NEK2A in human cancer and its therapeutic potentials.Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition An undecided coiled coil: the leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.Inhibition of Nek2 by small molecules affects proteasome activity.Targeting NEK2 as a promising therapeutic approach for cancer treatment.The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.Kinase packing defects as drug targets.Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis An essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites.Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity.Mitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cells.Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity.Cell cycle regulation by the NEK family of protein kinases.On the molecular mechanisms of mitotic kinase activation.CEP proteins: the knights of centrosome dynasty.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.The structural mechanisms that underpin mitotic kinase activation.Structure, function, and evolution of plant NIMA-related kinases: implication for phosphorylation-dependent microtubule regulation.Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1 The hunt for antimitotic agents: an overview of structure-based design strategies.

P2860

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P2860

Structure and regulation of the human Nek2 centrosomal kinase

http://www.wikidata.org/entity/Q27643463

description

2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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name

Structure and regulation of the human Nek2 centrosomal kinase

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Structure and regulation of the human Nek2 centrosomal kinase

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Structure and regulation of the human Nek2 centrosomal kinase

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type

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Structure and regulation of the human Nek2 centrosomal kinase

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Structure and regulation of the human Nek2 centrosomal kinase

@en

Structure and regulation of the human Nek2 centrosomal kinase

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prefLabel

Structure and regulation of the human Nek2 centrosomal kinase

@ast

Structure and regulation of the human Nek2 centrosomal kinase

@en

Structure and regulation of the human Nek2 centrosomal kinase

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Journal of Biological Chemistry

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Structure and regulation of the human Nek2 centrosomal kinase

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P2093

Andrew M Fry

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Ashley Pike

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Donna-Marie Parkinson

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Frank J Ivins

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Joanne E Baxter

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Peter Rellos

http://www.w3.org/2001/XMLSchema#string

Qi Yu Shen

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Sanjan Das

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Steven Howell

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P2860

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

Caught Nek-ing: cilia and centrioles

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

Rootletin forms centriole-associated filaments and functions in centrosome cohesion

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

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6833-42

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scholarly article

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2652657

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10.1074/JBC.M609721200

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P433

9

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P478

282

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Stephen J Smerdon

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2007-03-02T00:00:00Z

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17197699

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