Arginase-boronic acid complex highlights a physiological role in erectile function
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Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.Expression, purification, assay, and crystal structure of perdeuterated human arginase IEvolution of the arginase fold and functional diversityCrystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese clusterArginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxationArginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthmaProbing the Specificity Determinants of Amino Acid Recognition by Arginase † ‡Inhibition of human arginase I by substrate and product analogues2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase ICrystal Structure of Arginase from Plasmodium falciparum and Implications for l -Arginine Depletion in Malarial Infection,Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor DesignCrystal Structures of Complexes with Cobalt-Reconstituted Human Arginase ICrystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infectionsFormiminoglutamase from Trypanosoma Cruzi Is An Arginase-Like Manganese MetalloenzymeUnique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterasesCrystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of SchistosomiasisRegulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cellsArginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanismAnandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptorsRole of the nitric oxide-cyclic GMP pathway in regulation of vaginal blood flow.L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin.Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans.Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats.The second-shell metal ligands of human arginase affect coordination of the nucleophile and substrate.NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence.Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily.p38 Mitogen-activated protein kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated miceThe role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes.New approaches to the design and discovery of therapies to prevent erectile dysfunction.Arginase in retinopathy.Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function.Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.Crystallization and preliminary crystallographic studies of Helicobacter pylori arginaseArginase II deletion increases corpora cavernosa relaxation in diabetic mice.The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function.Endothelial dysfunction in diabetic erectile dysfunction.Arginase and vascular aging.Increased expression of the nitric oxide synthase gene and protein in corpus cavernosum by repeated dosing of udenafil in a rat model of chemical diabetogenesis.Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction.Development of novel arginase inhibitors for therapy of endothelial dysfunction
P2860
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P2860
Arginase-boronic acid complex highlights a physiological role in erectile function
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Arginase-boronic acid complex highlights a physiological role in erectile function
@ast
Arginase-boronic acid complex highlights a physiological role in erectile function
@en
Arginase-boronic acid complex highlights a physiological role in erectile function
@nl
type
label
Arginase-boronic acid complex highlights a physiological role in erectile function
@ast
Arginase-boronic acid complex highlights a physiological role in erectile function
@en
Arginase-boronic acid complex highlights a physiological role in erectile function
@nl
prefLabel
Arginase-boronic acid complex highlights a physiological role in erectile function
@ast
Arginase-boronic acid complex highlights a physiological role in erectile function
@en
Arginase-boronic acid complex highlights a physiological role in erectile function
@nl
P2093
P356
P1476
Arginase-boronic acid complex highlights a physiological role in erectile function
@en
P2093
A M Traish
D W Christianson
P2888
P304
P356
10.1038/14929
P577
1999-11-01T00:00:00Z
P5875
P6179
1051558896