Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation.
about
Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent mannerCalpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neuronsCalpain 6 is involved in microtubule stabilization and cytoskeletal organizationPEST sequences in the malaria parasite Plasmodium falciparum: a genomic studyA structural study for the optimisation of functional motifs encoded in protein sequencesMissense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breedThe atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degenerationSingle Cell Proteolytic Assays to Investigate Cancer Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading SchemeProtein-Protein Interactions between Hepatitis C Virus Nonstructural ProteinsCocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions #Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpainsSolution Structure of the Apo C-Terminal Domain of the Lethocerus F1 Troponin C IsoformCrystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-handThe yeast penta-EF protein Pef1p is involved in cation-dependent budding and cell polarization.Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29Origins of the difference in Ca2+ requirement for activation of mu- and m-calpainDetermination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactionsDisruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and divisionCharacterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localizationContribution of distinct structural elements to activation of calpain by Ca2+ ionsProteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3Calcium regulates tertiary structure and enzymatic activity of human endometase/matrilysin-2 and its role in promoting human breast cancer cell invasion.Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides.Homology modeling study of bovine μ-calpain inhibitor-binding domains.A New Insight into the Role of Calpains in Post-mortem Meat Tenderization in Domestic Animals: A review.A novel human small subunit of calpains.Disruption of the mouse mu-calpain gene reveals an essential role in platelet functionCalcium signaling: a tale for all seasonsCalpain function in the modulation of signal transduction molecules.Investigations into the membrane interactions of m-calpain domain V.Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatidsActivation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpainMembrane targeting by C1 and C2 domains.Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5).Massive expansion of the calpain gene family in unicellular eukaryotes.Calpain chronicle--an enzyme family under multidisciplinary characterizationVital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.Calpain dysregulation in Alzheimer's diseaseMembrane Repair: Mechanisms and Pathophysiology.Proteolytic mechanisms in necrotic cell death and neurodegeneration.
P2860
Q24291011-B1016603-E37D-4D4A-9364-4AEA7C1A953CQ24338621-12E73165-5A1B-4D72-8C64-7A6662E23E52Q24338909-7D8210E6-BE40-4C51-A158-3C7CBEFA0874Q24800952-66ED3FBB-F807-457B-B167-F4156959933DQ24806433-357E706F-CD14-475C-9133-49A061218476Q27318452-EEDA7135-B4AB-4557-91B5-76DC95FB87CEQ27334407-4E8C4E1A-3BDC-4031-8A8B-173D39D34A6EQ27347671-FDA0940E-0A11-4479-B41E-284F22F6E960Q27473469-640742F5-FF1A-4403-BCBE-4CCEFB3FE58FQ27651571-1858753E-2CD6-45CC-A3B4-8C54F845221BQ27652953-DD271A0D-6E95-4776-B4BA-64258F689C36Q27659213-756C9D0F-EEA1-4F05-B61A-15060A7CDE45Q27690270-6B3AD42B-D4CF-46EF-B499-062AE1565A29Q27933669-FBF87A41-EEE5-41E4-9E3A-EF5CC5DAEE59Q28215152-546644A0-33C3-4E87-9370-2CD245AFC755Q28217807-A537382B-BE43-4BED-B3BF-0F2A79D365E7Q28276503-8DB35A2B-AC23-41F3-B830-389DE8707C9AQ28512039-F76E9AF0-9685-45FD-AFE0-B60AC0C5CA44Q28576163-ABA641D5-997C-4603-B21A-93E8ECAA4749Q28577523-2E725695-26F5-43BA-A0FB-DA5E2832D6D2Q28776402-DE2DD2B3-1AE8-4CA1-B78F-567FFC3DD27AQ30358846-2C32E9E2-3115-4E4B-B197-AC7A2DC920C6Q33301065-2834D1C1-71CA-4ECD-B431-675F34A7C698Q33755662-45FF2FFC-E285-42F9-9C32-8AB97888D727Q33886192-1D416853-5DA5-414D-97F8-3BF10D52884BQ33957512-5699D90B-2B0C-4F12-8CDB-DF05BF4B76E1Q33967742-DB13B6D7-B56E-490A-918D-F791E75F4167Q34008291-DB908652-2C22-4EC3-9A09-B3B900ACA8A8Q34087813-97CEB437-0775-442C-9B09-EC55B2B105ACQ34189891-EC7F733F-0CC8-4A4B-AAF2-9EDE22376C73Q34272471-9D268405-B52A-4862-840C-28C7CA7575CEQ34277120-6CC1E976-1032-45FA-B515-A7C057212A85Q34296902-F15A5396-BFDE-4C30-BF5D-A4D22AA0E5ECQ34300862-73647231-8914-4458-8411-441C8AFF25A2Q34423812-DFE3A3AD-BEFF-49A2-878B-2BC79D4748D9Q35157505-5077BB95-844E-438A-A38F-8C8B930C69B8Q35273962-CE08201A-629A-4BA8-AFF2-F419B32FDE5AQ35361462-4C823ED0-0B8B-44D0-8385-AD84788704B6Q36146335-2C3183B3-D32E-4485-93F7-C9DF6EBD1A62Q36156010-F026C3E6-E2A9-4C1D-819D-7C0A6FBD35DA
P2860
Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of calpain r ...... vel mode of enzyme activation.
@ast
Crystal structure of calpain r ...... vel mode of enzyme activation.
@en
Crystal structure of calpain r ...... ovel mode of enzyme activation
@nl
type
label
Crystal structure of calpain r ...... vel mode of enzyme activation.
@ast
Crystal structure of calpain r ...... vel mode of enzyme activation.
@en
Crystal structure of calpain r ...... ovel mode of enzyme activation
@nl
prefLabel
Crystal structure of calpain r ...... vel mode of enzyme activation.
@ast
Crystal structure of calpain r ...... vel mode of enzyme activation.
@en
Crystal structure of calpain r ...... ovel mode of enzyme activation
@nl
P2093
P3181
P356
P1433
P1476
Crystal structure of calpain r ...... vel mode of enzyme activation.
@en
P2093
P304
P3181
P356
10.1093/EMBOJ/18.24.6880
P407
P577
1999-12-01T00:00:00Z