Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase
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Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMPProduct deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediateCrystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeletonCan sequence determine function?Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylaseStructural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylaseThe structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradationStructural Characterization of the Molecular Events during a Slow Substrate–Product Transition in Orotidine 5′-Monophosphate DecarboxylaseMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization ,Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active ConformationStructural determinants for the inhibitory ligands of orotidine-5′-monophosphate decarboxylaseDouble Duty for a Conserved Glutamate in Pyruvate Decarboxylase: Evidence of the Participation in Stereoelectronically Controlled Decarboxylation and in Protonation of the Nascent Carbanion/Enamine Intermediate,The Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationFrsA functions as a cofactor-independent decarboxylase to control metabolic fluxMechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding SiteConformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the EnzymeAtomic Resolution Structure of the Orotidine 5'-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISMComputational, Structural, and Kinetic Evidence That Vibrio vulnificus FrsA Is Not a Cofactor-Independent Pyruvate DecarboxylaseEmergent Decarboxylase Activity and Attenuation of α/β-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in TomatoSubstrate Distortion Contributes to the Catalysis of Orotidine 5′-Monophosphate DecarboxylaseSub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediateUracil-DNA glycosylase acts by substrate autocatalysisMolecular dynamics study of active-site interactions with tetracoordinate transients in acetylcholinesterase and its mutantsProton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituentInternal Dynamics of a Coarse-Grained Protein Using Analytical Harmonic Representation.Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.Ab initio quantum chemistry: methodology and applicationsProduct deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.Molecular dynamic study of orotidine-5'-monophosphate decarboxylase in ground state and in intermediate state: a role of the 203-218 loop dynamics.On catalytic preorganization in oxyanion holes: highlighting the problems with the gas-phase modeling of oxyanion holes and illustrating the need for complete enzyme models.Protein function annotation with Structurally Aligned Local Sites of Activity (SALSAs)Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution.Barrier passage and protein dynamics in enzymatically catalyzed reactions.Kinetic isotope effects of L-Dopa decarboxylase.Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMPQM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysisPolarization in the structures of uracil and thiouracils: Implication for binding with orotidine 5'-monophosphate decarboxylaseMechanisms and free energies of enzymatic reactions.Using catalytic atom maps to predict the catalytic functions present in enzyme active sites.Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.
P2860
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P2860
Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@ast
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@en
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@nl
type
label
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@ast
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@en
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@nl
prefLabel
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@ast
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@en
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@nl
P2093
P2860
P356
P1476
Electrostatic stress in cataly ...... ne monophosphate decarboxylase
@en
P2093
P2860
P304
P356
10.1073/PNAS.050417797
P407
P577
2000-02-29T00:00:00Z