Peptide exosite inhibitors of factor VIIa as anticoagulants - Test2 - elhamkhani - TriplyDB

Peptide exosite inhibitors of factor VIIa as anticoagulants

Peptide exosite inhibitors of factor VIIa as anticoagulants

http://www.wikidata.org/entity/Q27622190

about

Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor Crystal structure of an anticoagulant protein in complex with the Gla domain of factor X Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor.Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1 Discovery of an allosteric site in the caspases Engineering exosite peptides for complete inhibition of factor VIIa using a protease switch with substrate phage.Exploring protein-protein interactions with phage display.Disulfide locked variants of factor VIIa with a restricted beta-strand conformation have enhanced enzymatic activity Peptide inhibitor of pancreatic lipase selected by phage display using different elution strategies.The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding.Identification of target ligands of CORYNE in Arabidopsis by phage display library.Identification of cyclic peptides able to mimic the functional epitope of IgG1-Fc for human Fc gammaRI.Allosteric regulation of protease activity by small molecules.Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107 Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.The N-terminal epidermal growth factor-like domain in factor IX and factor X represents an important recognition motif for binding to tissue factor.Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.Allosteric inhibition of the neuropeptidase neurolysin.Survey of the year 2000 commercial optical biosensor literature.In Silico Design of Novel Anticoagulant Peptides targeting Blood Coagulation Factor VIIa.Tissue factor - a therapeutic target for thrombotic disorders.Using fluorogenic peptide substrates to assay matrix metalloproteinases.Discovery methodology for the development of direct factor VIIa inhibitors.Allostery in trypsin-like proteases suggests new therapeutic strategies.Conformational selection in trypsin-like proteases.Beyond Antibodies: Development of a Novel Protein Scaffold Based on Human Chaperonin 10.Design and development of molecular imaging probes.Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors.Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex.Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.Atomic-resolution conformational analysis of the GM3 ganglioside in a lipid bilayer and its implications for ganglioside-protein recognition at membrane surfaces.Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.Pseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer.Mechanisms of macromolecular protease inhibitors

P2860

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P2860

Peptide exosite inhibitors of factor VIIa as anticoagulants

http://www.wikidata.org/entity/Q27622190

description

2000 nî lūn-bûn

@nan

2000 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի մարտին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Peptide exosite inhibitors of factor VIIa as anticoagulants

@ast

Peptide exosite inhibitors of factor VIIa as anticoagulants

@en

Peptide exosite inhibitors of factor VIIa as anticoagulants

@nl

type

label

Peptide exosite inhibitors of factor VIIa as anticoagulants

@ast

Peptide exosite inhibitors of factor VIIa as anticoagulants

@en

Peptide exosite inhibitors of factor VIIa as anticoagulants

@nl

prefLabel

Peptide exosite inhibitors of factor VIIa as anticoagulants

@ast

Peptide exosite inhibitors of factor VIIa as anticoagulants

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Peptide exosite inhibitors of factor VIIa as anticoagulants

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Peptide exosite inhibitors of factor VIIa as anticoagulants

@en

P2093

C Eigenbrot

http://www.w3.org/2001/XMLSchema#string

L Santell

http://www.w3.org/2001/XMLSchema#string

M A Dwyer

http://www.w3.org/2001/XMLSchema#string

M H Ultsch

http://www.w3.org/2001/XMLSchema#string

M P O'Connell

http://www.w3.org/2001/XMLSchema#string

M S Dennis

http://www.w3.org/2001/XMLSchema#string

N J Skelton

http://www.w3.org/2001/XMLSchema#string

R A Lazarus

http://www.w3.org/2001/XMLSchema#string

P2860

Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

Structure of human factor VIIa and its implications for the triggering of blood coagulation

Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla)

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant

Rapid and efficient site-specific mutagenesis without phenotypic selection

Regulation of coagulation by a multivalent Kunitz-type inhibitor

Serine proteases: structure and mechanism of catalysis

P2888

P304

465-70

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scholarly article

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1656432

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10.1038/35006574

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P433

6777

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P478

404

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2000-03-30T00:00:00Z

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12554428

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1039681707

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10761907

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P921

anticoagulation