Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion
about
Circularly permuted proteins in the protein structure databaseGH97 is a new family of glycoside hydrolases, which is related to the alpha-galactosidase superfamily.Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestryCrystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediateCan sequence determine function?Two-step Ligand Binding in a (βα)8 Barrel Enzyme: SUBSTRATE-BOUND STRUCTURES SHED NEW LIGHT ON THE CATALYTIC CYCLE OF HisAStructural insight into gene duplication, gene fusion and domain swapping in the evolution of PLP-independent amino acid racemasesCrystal structure of glutamine amidotransferase fromThermotoga maritimaEvolution of feedback-inhibited / barrel isoenzymes by gene duplication and a single mutationMimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activityAccommodation of a highly symmetric core within a symmetric protein superfoldCrystal structure of imidazole glycerol-phosphate dehydratase: duplication of an unusual foldStructure of amidase from Pseudomonas aeruginosa showing a trapped acyl transfer reaction intermediate stateA -barrel built by the combination of fragments from different foldsStructural Basis for Substrate Specificity in Phosphate Binding (β/α) 8 -Barrels: d -Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12 † ‡The crystal structure of galacto-N-biose/lacto-N-biose I phosphorylase: a large deformation of a TIM barrel scaffoldEstablishing wild-type levels of catalytic activity on natural and artificial ( )8-barrel protein scaffoldsMetamorphic proteins mediate evolutionary transitions of structureBisubstrate specificity in histidine/tryptophan biosynthesis isomerase from Mycobacterium tuberculosis by active site metamorphosisSymerythrin Structures at Atomic Resolution and the Origins of Rubrerythrins and the Ferritin-Like SuperfamilyExploring Symmetry as an Avenue to the Computational Design of Large Protein DomainsIterative approach to computational enzyme designA sugar isomerization reaction established on various (βα)₈-barrel scaffolds is based on substrate-assisted catalysisEstablishing catalytic activity on an artificial (βα)8-barrel protein designed from identical half-barrelsEvolutionary relationship of two ancient protein superfoldsTwo independently folding units of Plasmodium profilin suggest evolution via gene fusionArchaeal fructose-1,6-bisphosphate aldolases constitute a new family of archaeal type class I aldolaseThe TIM-barrel fold: a versatile framework for efficient enzymesPerturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella entericaOccurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesisAlternative splice variants in TIM barrel proteins from human genome correlate with the structural and evolutionary modularity of this versatile protein foldA Robust and Versatile Method of Combinatorial Chemical Synthesis of Gene Libraries via Hierarchical Assembly of Partially Randomized ModulesThe TIM Barrel Architecture Facilitated the Early Evolution of Protein-Mediated MetabolismPerennial stream discharge in the hyperarid Atacama Desert of northern Chile during the latest PleistoceneThe interaction of ammonia and xenon with the imidazole glycerol phosphate synthase from Thermotoga maritima as detected by NMR spectroscopy.Mimicking enzyme evolution by generating new (betaalpha)8-barrels from (betaalpha)4-half-barrels.Alternative splicing and protein structure evolution.Domain atrophy creates rare cases of functional partial protein domainsStructural and functional modularity of proteins in the de novo purine biosynthetic pathway.
P2860
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P2860
Structural evidence for evolution of the beta/alpha barrel scaffold by gene duplication and fusion
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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Structural evidence for evolut ...... by gene duplication and fusion
@ast
Structural evidence for evolut ...... by gene duplication and fusion
@en
Structural evidence for evolut ...... by gene duplication and fusion
@nl
type
label
Structural evidence for evolut ...... by gene duplication and fusion
@ast
Structural evidence for evolut ...... by gene duplication and fusion
@en
Structural evidence for evolut ...... by gene duplication and fusion
@nl
prefLabel
Structural evidence for evolut ...... by gene duplication and fusion
@ast
Structural evidence for evolut ...... by gene duplication and fusion
@en
Structural evidence for evolut ...... by gene duplication and fusion
@nl
P2093
P1433
P1476
Structural evidence for evolut ...... by gene duplication and fusion
@en
P2093
P304
P356
10.1126/SCIENCE.289.5484.1546
P407
P577
2000-09-01T00:00:00Z