A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease
about
Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug DesignStructural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepaticaNovel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteasesNonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease ChemotherapyIn Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruziStructural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoniTurnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural InsightsThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsComputational identification of uncharacterized cruzain binding sitesNovel Non-Peptide Inhibitors against SmCL1 of Schistosoma mansoni: In Silico Elucidation, Implications and Evaluation via Knowledge Based Drug DiscoveryReversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides.Congopain from Trypanosoma congolense: drug target and vaccine candidate.Novel cruzain inhibitors for the treatment of Chagas' disease.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies.Synthesis of macrocyclic trypanosomal cysteine protease inhibitors.Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host.Looking at the proteases from a simple perspective.Toward the discovery of inhibitors of babesipain-1, a Babesia bigemina cysteine protease: in vitro evaluation, homology modeling and molecular docking studies.Repositioning FDA Drugs as Potential Cruzain Inhibitors from Trypanosoma cruzi: Virtual Screening, In Vitro and In Vivo Studies.Molecular dynamics studies of caspase-3.The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin.Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi.Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors.Structural characterization of vivapain-2 and vivapain-3, cysteine proteases from Plasmodium vivax: comparative protein modeling and docking studies.Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targets.Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor.Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum.Synthesis of Unprecedented Sulfonylated Phosphono-exo-Glycals Designed as Inhibitors of the Three Mycobacterial Galactofuranose Processing Enzymes.Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipainRational Selection of Anti-Microbial Drug Targets: Unique or Conserved?
P2860
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P2860
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A target within the target: pr ...... r the Chagas' disease protease
@ast
A target within the target: pr ...... r the Chagas' disease protease
@en
A target within the target: pr ...... r the Chagas' disease protease
@nl
type
label
A target within the target: pr ...... r the Chagas' disease protease
@ast
A target within the target: pr ...... r the Chagas' disease protease
@en
A target within the target: pr ...... r the Chagas' disease protease
@nl
prefLabel
A target within the target: pr ...... r the Chagas' disease protease
@ast
A target within the target: pr ...... r the Chagas' disease protease
@en
A target within the target: pr ...... r the Chagas' disease protease
@nl
P2093
P1433
P1476
A target within the target: pr ...... r the Chagas' disease protease
@en
P2093
J H McKerrow
L S Brinen
R J Fletterick
P304
P356
10.1016/S0969-2126(00)00173-8
P577
2000-08-15T00:00:00Z