Structural insights into the mode of action of a pure antiestrogen
about
The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductulesAdvances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapyProbing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor.Structural insights into corepressor recognition by antagonist-bound estrogen receptorsThe 2.0 Å crystal structure of the ERα ligand-binding domain complexed with lasofoxifeneStructural plasticity in the oestrogen receptor ligand-binding domainCrystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanismNFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analysesPrediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical methodStructure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor ModulatorsStructural Basis of Digoxin That Antagonizes ROR t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 ProductionAntiestrogens: structure-activity relationships and use in breast cancer treatmentStructural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking.A novel pesticide-induced conformational state of the oestrogen receptor ligand-binding domain, detected by conformation-specific peptide binding.Ligands specify estrogen receptor alpha nuclear localization and degradationEstrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vesselsDesign, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents.Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).The multifaceted mechanisms of estradiol and estrogen receptor signaling.Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.Estrogen receptor ligands: a patent review update.Versatility or promiscuity: the estrogen receptors, control of ligand selectivity and an update on subtype selective ligands.Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease.Different ligands-different receptor conformations: modeling of the hER alpha LBD in complex with agonists and antagonists.Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism.Differential SERM effects on corepressor binding dictate ERalpha activity in vivo.Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis.Pharmacological relevance of endoxifen in a laboratory simulation of breast cancer in postmenopausal patients.A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta.The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacyAn intramolecular folding sensor for imaging estrogen receptor-ligand interactions.Structural insights into selective agonist actions of tamoxifen on human estrogen receptor alpha.Emerging principles for the development of resistance to antihormonal therapy: implications for the clinical utility of fulvestrant.The terminal substituents of 7α, 6-hexanyl derivatives of estradiol determine their selective estrogen receptor modulator versus agonist activities.Design, synthesis, and initial biological evaluation of a steroidal anti-estrogen-doxorubicin bioconjugate for targeting estrogen receptor-positive breast cancer cells.In-vitro antiproliferative activity of benzopyranone derivatives in comparison with standard chemotherapeutic drugsRole of SUMOylation in full antiestrogenicityMolecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds.Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using "click" chemistry.
P2860
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P2860
Structural insights into the mode of action of a pure antiestrogen
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structural insights into the mode of action of a pure antiestrogen
@ast
Structural insights into the mode of action of a pure antiestrogen
@en
Structural insights into the mode of action of a pure antiestrogen
@nl
type
label
Structural insights into the mode of action of a pure antiestrogen
@ast
Structural insights into the mode of action of a pure antiestrogen
@en
Structural insights into the mode of action of a pure antiestrogen
@nl
prefLabel
Structural insights into the mode of action of a pure antiestrogen
@ast
Structural insights into the mode of action of a pure antiestrogen
@en
Structural insights into the mode of action of a pure antiestrogen
@nl
P2093
P1433
P1476
Structural insights into the mode of action of a pure antiestrogen
@en
P2093
A G Thorsell
A M Brzozowski
J A Gustafsson
M Carlquist
R E Hubbard
P304
P356
10.1016/S0969-2126(01)00568-8
P50
P577
2001-02-01T00:00:00Z