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Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activationActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesStructure of human factor VIIa and its implications for the triggering of blood coagulationStructure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptorStructural insights into the mode of action of a pure antiestrogenStructure of dystrophia myotonica protein kinaseStructural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin LigaseThe p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structureThe structural basis of ZMPSTE24-dependent laminopathiesK2P channel gating mechanisms revealed by structures of TREK-2 and a complex with ProzacCrystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthaseMolecular basis of agonism and antagonism in the oestrogen receptorAn overview of heavy-atom derivatization of protein crystalsMolecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2Squeezing the most from every crystal: the fine details of data collection.A structural biologist's view of the oestrogen receptor.Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structuresA prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligasesStructures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic DesignStructural insights into the mechanisms of agonism and antagonism in oestrogen receptor isoformsX-ray crystallography of agonist/antagonist-bound receptorsAndrogen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swappingNovel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domainA pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channelsThe structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16KA lower X-gate in TASK channels traps inhibitors within the vestibule
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wetenschapper
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A C Pike
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A C Pike
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P106
P31
P496
0000-0001-9661-2607