Structural mechanism for statin inhibition of HMG-CoA reductase
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Genome-wide association studies in an isolated founder population from the Pacific Island of KosraeThe 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductasesStatins versus placebo for people with chronic obstructive pulmonary disease (COPD)Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsisStatins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitisStatins for non-alcoholic steatohepatitisRosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspectivePleiotropic effects of statinsDoes simvastatin stimulate bone formation in vivo?The Interaction Between Statins and Exercise: Mechanisms and Strategies to Counter the Musculoskeletal Side Effects of This Combination TherapyCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisA Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway EngineeringAnticoagulants and Statins As Pharmacological Agents in Free Flap Surgery: Current RationaleEffects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsMevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible LinkStatins as regulators of redox state in the vascular endothelium: beyond lipid loweringTrendspotting in the Protein Data BankRole of lipotoxicity in endothelial dysfunctionModulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacologyA novel therapeutic effect of statins on nephrogenic diabetes insipidusPotential role of nonstatin cholesterol lowering agentsTargeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductaseDirected Evolution and Structural Characterization of a Simvastatin SynthaseStructural insight for substrate tolerance to 2-deoxyribose-5-phosphate aldolase from the pathogen Streptococcus suisFunctional characterization of the vitamin K2 biosynthetic enzyme UBIAD1An overview of the synthetic routes to the best selling drugs containing 6-membered heterocyclesExploration of virtual candidates for human HMG-CoA reductase inhibitors using pharmacophore modeling and molecular dynamics simulationsHarnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue DrugsAn inquiry into protein structure and genetic disease: introducing undergraduates to bioinformatics in a large introductory courseAutoSite: an automated approach for pseudo-ligands prediction-from ligand-binding sites identification to predicting key ligand atoms.Mechanistic systems modeling to guide drug discovery and developmentThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases.The significance of chirality in drug design and development.Effects of hypocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German cockroach.Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase lower fecundity in the German cockroach: correlation between the effects on fecundity in vivo with the inhibition of enzymatic activity in embryo cells.Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cellsNovel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statinsEffects of lovastatin on breast cancer cells: a proteo-metabonomic study.
P2860
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P2860
Structural mechanism for statin inhibition of HMG-CoA reductase
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structural mechanism for statin inhibition of HMG-CoA reductase
@ast
Structural mechanism for statin inhibition of HMG-CoA reductase
@en
Structural mechanism for statin inhibition of HMG-CoA reductase
@nl
type
label
Structural mechanism for statin inhibition of HMG-CoA reductase
@ast
Structural mechanism for statin inhibition of HMG-CoA reductase
@en
Structural mechanism for statin inhibition of HMG-CoA reductase
@nl
prefLabel
Structural mechanism for statin inhibition of HMG-CoA reductase
@ast
Structural mechanism for statin inhibition of HMG-CoA reductase
@en
Structural mechanism for statin inhibition of HMG-CoA reductase
@nl
P3181
P356
P1433
P1476
Structural mechanism for statin inhibition of HMG-CoA reductase
@en
P2093
E S Istvan
P304
P3181
P356
10.1126/SCIENCE.1059344
P407
P577
2001-05-11T00:00:00Z