Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites
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Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active siteCrystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex †Discovery of potent pteridine reductase inhibitors to guide antiparasite drug developmentOne Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual ScreeningStructure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the LeishmaniasesHigh-resolution structures ofTrypanosoma bruceipteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug targetStructure of recombinantLeishmania donovanipteridine reductase reveals a disordered active siteAcinetobacter baumanniiFolD ligand complexes - potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetasesAssessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug TargetStructural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preferenceStructure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1The first crystal structure of NAD-dependent 3-dehydro-2-deoxy-D-gluconate dehydrogenase from Thermus thermophilus HB8Structure, Activity and Stereoselectivity of NADPH-Dependent Oxidoreductases Catalysing the S-Selective Reduction of the Imine Substrate 2-MethylpyrrolineThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsFolX and FolM are essential for tetrahydromonapterin synthesis in Escherichia coli and Pseudomonas aeruginosaComparative genomics of bacterial and plant folate synthesis and salvage: predictions and validationsSynthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in miceIn silico screening, structure-activity relationship, and biologic evaluation of selective pteridine reductase inhibitors targeting visceral leishmaniasis.Promising therapeutic targets for antileishmanial drugs.A Pterin-Dependent Signaling Pathway Regulates a Dual-Function Diguanylate Cyclase-Phosphodiesterase Controlling Surface Attachment in Agrobacterium tumefaciens.Searching sequence space: two different approaches to dihydrofolate reductase catalysis.Anti-antimicrobial peptides: folding-mediated host defense antagonists.Folate metabolic pathways in LeishmaniaA structurally conserved water molecule in Rossmann dinucleotide-binding domains.Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.Classification of ligand molecules in PDB with graph match-based structural superposition.In-silico Leishmania target selectivity of antiparasitic terpenoids.Interactions of antiparasitic alkaloids with Leishmania protein targets: a molecular docking analysis.Mechanisms of Resistance to Folate Pathway Inhibitors in Burkholderia pseudomallei: Deviation from the Norm.FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli.Application of a simple quantum chemical approach to ligand fragment scoring for Trypanosoma brucei pteridine reductase 1 inhibition.Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose.Nonflowering plants possess a unique folate-dependent phenylalanine hydroxylase that is localized in chloroplasts.Molecular docking, structure-activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani.The epimerase activity of anthocyanidin reductase from Vitis vinifera and its regiospecific hydride transfers.Leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of Piper longum.Pharmacophore Mapping, In Silico Screening and Molecular Docking to Identify Selective Trypanosoma brucei Pteridine Reductase Inhibitors.
P2860
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P2860
Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@ast
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@en
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@nl
type
label
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@ast
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@en
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@nl
prefLabel
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@ast
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@en
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@nl
P2093
P356
P1476
Pteridine reductase mechanism ...... ce in trypanosomatid parasites
@en
P2093
A W Schüttelkopf
D G Gourley
G A Leonard
S M Beverley
W N Hunter
P356
10.1038/88584
P577
2001-06-01T00:00:00Z