Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease
about
Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageOne site mutation disrupts dimer formation in human DPP-IV proteinsCurrent and potential treatments for ubiquitous but neglected herpesvirus infectionsSubstrate Modulation of Enzyme Activity in the Herpesvirus Protease FamilyBroad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesDimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine ProteaseCommunication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.Inhibition of a viral enzyme by a small-molecule dimer disruptor.Allosteric regulation of protease activity by small molecules.Dimerization capacities of FGF2 purified with or without heparin-affinity chromatographyNon-nucleoside inhibitors of herpesviruses.Soluble expression, purification, and characterization of active recombinant human tissue plasminogen activator by auto-induction in E. coliEnzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV)Glutamate racemase dimerization inhibits dynamic conformational flexibility and reduces catalytic rates.Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease.Anti-herpesvirus agents: a patent and literature review (2003 to present).Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.Cytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin)Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-throughput format.Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
P2860
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P2860
Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@ast
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@en
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@nl
type
label
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@ast
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@en
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@nl
prefLabel
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@ast
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@en
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@nl
P2093
P356
P1476
Molecular mechanism for dimeri ...... human cytomegalovirus protease
@en
P2093
P2888
P356
10.1038/NSB0901-810
P577
2001-09-01T00:00:00Z
P5875
P6179
1005177035