Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase - Test2 - elhamkhani - TriplyDB

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

http://www.wikidata.org/entity/Q27636019

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Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations Peptide Length and Leaving-Group Sterics Influence Potency of Peptide Phosphonate Protease Inhibitors Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1 A Reverse Binding Motif That Contributes to Specific Protease Inhibition by Antibodies Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1 Functional and Structural Characterization of Vibrio cholerae Extracellular Serine Protease B, VesB Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition.Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.Protein interaction analysis of ST14 domains and their point and deletion mutants.Inhibition of human matriptase by eglin c variants.Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries Pericellular proteolysis in cancer Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesis A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway Energetic and structural basis for activation of the epithelial sodium channel by matriptase Transmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): expression and prognostic value in ovarian cancer.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.Membrane-anchored serine proteases in health and disease.Ranking protein-protein docking results using steered molecular dynamics and potential of mean force calculations Examining the assumptions underlying continuum-solvent models.Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).Structural and mechanistic insight into how antibodies inhibit serine proteases.Mutation G827R in matriptase causing autosomal recessive ichthyosis with hypotrichosis yields an inactive protease.HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors.A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces.Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation.Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).ENaC proteolytic regulation by channel-activating protease 2.Molecular genetic analysis of the hepatocyte growth factor/MET signaling pathway in pediatric medulloblastoma.

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P2860

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

http://www.wikidata.org/entity/Q27636019

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2002 nî lūn-bûn

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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2002 թվականի հունվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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Journal of Biological Chemistry

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Catalytic domain structures of ...... ransmembrane serine proteinase

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P2093

Diane Pierson

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Edgar Ong

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Edwin L Madison

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Gary Coombs

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Michael Hunter

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Pablo Fuentes-Prior

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Rainer Friedrich

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Richard Gonzalez

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Robert Huber

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Ryan Oehler

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P2860

Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor

Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module

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2869717

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10.1074/JBC.M109830200

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3

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277

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11696548

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transmembrane protein