The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism
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Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesisA Novel Adenylate Binding Site Confers Phosphopantetheine Adenylyltransferase Interactions with Coenzyme AGlycerol-3-phosphate cytidylyltransferase. Structural changes induced by binding of CDP-glycerol and the role of lysine residues in catalysisCrystal Structure of a Mammalian CTP: Phosphocholine Cytidylyltransferase Catalytic Domain Reveals Novel Active Site Residues within a Highly Conserved Nucleotidyltransferase FoldThe structure ofStaphylococcus aureusphosphopantetheine adenylyltransferase in complex with 3′-phosphoadenosine 5′-phosphosulfate reveals a new ligand-binding modeStructure ofMycobacterium tuberculosisphosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformationStructures of phosphopantetheine adenylyltransferase from Burkholderia pseudomalleiCrystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheineDiscovery of Inhibitors of 4'-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial TherapyX-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reactionFacilitating unambiguous NMR assignments and enabling higher probe density through selective labeling of all methyl containing amino acidsSubstrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferaseExperimentally validated novel inhibitors of Helicobacter pylori phosphopantetheine adenylyltransferase discovered by virtual high-throughput screeningIdentification, purification, and characterization of an eukaryotic-like phosphopantetheine adenylyltransferase (coenzyme A biosynthetic pathway) in the hyperthermophilic archaeon Pyrococcus abyssi.The puzzle of ligand binding to Corynebacterium ammoniagenes FAD synthetaseStructural analysis of FAD synthetase from Corynebacterium ammoniagenes.Detailed analysis of function divergence in a large and diverse domain superfamily: toward a refined protocol of function classificationOverexpression, crystallization and preliminary X-ray crystallographic analysis of phosphopantetheine adenylyltransferase from Enterococcus faecalisInhibiting bacterial fatty acid synthesis.Capture and quality control mechanisms for adenosine-5'-triphosphate binding.Biosynthesis of Pantothenic Acid and Coenzyme A.Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes.Role of key residues at the flavin mononucleotide (FMN):adenylyltransferase catalytic site of the bifunctional riboflavin kinase/flavin adenine dinucleotide (FAD) Synthetase from Corynebacterium ammoniagenes.Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis.The coenzyme a biosynthetic enzyme phosphopantetheine adenylyltransferase plays a crucial role in plant growth, salt/osmotic stress resistance, and seed lipid storage.Crystal structure of D-glycero-Β-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.Substitution of asparagine 76 by a tyrosine residue induces domain swapping in Helicobacter pylori phosphopantetheine adenylyltransferase.
P2860
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P2860
The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism
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2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2002 թվականի հունվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
The crystal structures of phos ...... e enzyme's catalytic mechanism
@ast
The crystal structures of phos ...... e enzyme's catalytic mechanism
@en
The crystal structures of phos ...... e enzyme's catalytic mechanism
@nl
type
label
The crystal structures of phos ...... e enzyme's catalytic mechanism
@ast
The crystal structures of phos ...... e enzyme's catalytic mechanism
@en
The crystal structures of phos ...... e enzyme's catalytic mechanism
@nl
prefLabel
The crystal structures of phos ...... e enzyme's catalytic mechanism
@ast
The crystal structures of phos ...... e enzyme's catalytic mechanism
@en
The crystal structures of phos ...... e enzyme's catalytic mechanism
@nl
P356
P1476
The crystal structures of phos ...... e enzyme's catalytic mechanism
@en
P304
P356
10.1006/JMBI.2001.5272
P407
P50
P577
2002-01-25T00:00:00Z