Crystal Structure of a Mammalian CTP: Phosphocholine Cytidylyltransferase Catalytic Domain Reveals Novel Active Site Residues within a Highly Conserved Nucleotidyltransferase Fold
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Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactorStructure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domainStructural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic HelixBiochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is activeAnalysis of the protein domain and domain architecture content in fungi and its application in the search of new antifungal targetsPlasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screeningMutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver diseaseMolecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine CytidylyltransferaseStructure of a CGI-58 motif provides the molecular basis of lipid droplet anchoringPhosphatidylcholine and the CDP-choline cycle.Mutations in PCYT1A, encoding a key regulator of phosphatidylcholine metabolism, cause spondylometaphyseal dysplasia with cone-rod dystrophy.Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy.Isoform-specific and protein kinase C-mediated regulation of CTP:phosphoethanolamine cytidylyltransferase phosphorylationA 22-mer segment in the structurally pliable regulatory domain of metazoan CTP: phosphocholine cytidylyltransferase facilitates both silencing and activating functions.The intrinsically disordered nuclear localization signal and phosphorylation segments distinguish the membrane affinity of two cytidylyltransferase isoforms.Crystal structure of D-glycero-Β-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates.Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.An auto-inhibitory helix in CTP:phosphocholine cytidylyltransferase hi-jacks the catalytic residue and constrains a pliable, domain-bridging helix pair.PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis
P2860
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P2860
Crystal Structure of a Mammalian CTP: Phosphocholine Cytidylyltransferase Catalytic Domain Reveals Novel Active Site Residues within a Highly Conserved Nucleotidyltransferase Fold
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@ast
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@en
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@nl
type
label
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@ast
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@en
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@nl
prefLabel
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@ast
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@en
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@nl
P2093
P2860
P356
P1476
Crystal Structure of a Mammali ...... ed Nucleotidyltransferase Fold
@en
P2093
Jaeyong Lee
Joanne Johnson
Rosemary B Cornell
Ziwei Ding
P2860
P304
P356
10.1074/JBC.M109.053363
P407
P50
P577
2009-11-27T00:00:00Z