The structural basis of localization and signaling by the focal adhesion targeting domain
about
Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrityStructural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101Paxillin comes of ageStructural basis for the autoinhibition of focal adhesion kinaseNMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding modelGIT1 Paxillin-binding Domain Is a Four-helix Bundle, and It Binds to Both Paxillin LD2 and LD4 MotifsCrystal Structure of PAV1-137: A Protein from the Virus PAV1 That InfectsPyrococcus abyssiFAK dimerization controls its kinase-dependent functions at focal adhesionsPhosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changesMolecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycleThe serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundleRegulation of invasive behavior by vascular endothelial growth factor is HEF1-dependentA Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.Dynamics and mechanism of p130Cas localization to focal adhesionsConformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.FERM domain interaction promotes FAK signaling.A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.Organization and post-transcriptional processing of focal adhesion kinase gene.A novel protocol of whole mount electro-immunofluorescence stainingPreliminary crystallographic characterization of the Grb2 SH2 domain in complex with a FAK-derived phosphotyrosyl peptidePhosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase.Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions.ILK mediates the effects of strain on intestinal epithelial wound closureNuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.New insights into FAK phosphorylation based on a FAT domain-defective mutationHow focal adhesion kinase achieves regulation by linking ligand binding, localization and actionNovel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activityImpaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.In vitro phosphorylation of the focal adhesion targeting domain of focal adhesion kinase by Src kinase.Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.Deciphering Mode of Action of Functionally Important Regions in the Intrinsically Disordered Paxillin (Residues 1-313) Using Its Interaction with FAT (Focal Adhesion Targeting Domain of Focal Adhesion Kinase).Human apolipoprotein(a) kringle V inhibits ischemia-induced retinal neovascularization via suppression of fibronectin-mediated angiogenesis.Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillinNovel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis.Structure and mechanics of integrin-based cell adhesion.Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group.Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domainsSmall molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.
P2860
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P2860
The structural basis of localization and signaling by the focal adhesion targeting domain
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The structural basis of localization and signaling by the focal adhesion targeting domain
@ast
The structural basis of localization and signaling by the focal adhesion targeting domain
@en
The structural basis of localization and signaling by the focal adhesion targeting domain
@nl
type
label
The structural basis of localization and signaling by the focal adhesion targeting domain
@ast
The structural basis of localization and signaling by the focal adhesion targeting domain
@en
The structural basis of localization and signaling by the focal adhesion targeting domain
@nl
prefLabel
The structural basis of localization and signaling by the focal adhesion targeting domain
@ast
The structural basis of localization and signaling by the focal adhesion targeting domain
@en
The structural basis of localization and signaling by the focal adhesion targeting domain
@nl
P3181
P1433
P1476
The structural basis of localization and signaling by the focal adhesion targeting domain
@en
P2093
Maria K Hoellerer
P304
P3181
P356
10.1016/S0969-2126(02)00717-7
P407
P577
2002-03-01T00:00:00Z