Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export
about
Structural evolution of the protein kinase-like superfamilyA novel role for MAPKAPK2 in morphogenesis during zebrafish developmentCrystal structure of the p38 alpha-MAPKAP kinase 2 heterodimerDNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilizationMAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 bindingActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progressionActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesThe N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localizationA p38 substrate-specific MK2-EGFP translocation assay for identification and validation of new p38 inhibitors in living cells: a comprising alternative for acquisition of cellular p38 inhibition dataMolecular basis of MAPK-activated protein kinase 2:p38 assemblyHigh-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligandThe Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3: Figure 1ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsRational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study.Design of a bioactive cell-penetrating peptide: when a transduction domain does more than transduceAttributes of short linear motifs.DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer.Phosphorylation and function of the kaposin B direct repeats of Kaposi's sarcoma-associated herpesvirus.Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells.The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylationStructural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.Prediction of leucine-rich nuclear export signal containing proteins with NESsentialCCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells.Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stressA comprehensive map of the toll-like receptor signaling network.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical TrialsPhosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression.p38 mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 (MK2) signaling in atrophic and hypertrophic denervated mouse skeletal muscleLow-molecular-weight MK2 inhibitors: a tough nut to crack!Ste20-like kinase SLK, at the crossroads: a matter of life and deathMechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes.Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2.Identifying protein construct variants with increased crystallization propensity--a case study.
P2860
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P2860
Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Structure of mitogen-activated ...... activation with nuclear export
@ast
Structure of mitogen-activated ...... activation with nuclear export
@en
Structure of mitogen-activated ...... activation with nuclear export
@nl
type
label
Structure of mitogen-activated ...... activation with nuclear export
@ast
Structure of mitogen-activated ...... activation with nuclear export
@en
Structure of mitogen-activated ...... activation with nuclear export
@nl
prefLabel
Structure of mitogen-activated ...... activation with nuclear export
@ast
Structure of mitogen-activated ...... activation with nuclear export
@en
Structure of mitogen-activated ...... activation with nuclear export
@nl
P2093
P2860
P356
P1476
Structure of mitogen-activated ...... activation with nuclear export
@en
P2093
Anne E Behrens
Ernst Ter Haar
John R Fulghum
Judith A Lippke
Koto Hayakawa
Lora L Swenson
Matthew J Fitzgibbon
P2860
P304
P356
10.1074/JBC.C200418200
P407
P577
2002-10-04T00:00:00Z