Molecular basis of MAPK-activated protein kinase 2:p38 assembly
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Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylationA distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cellsActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesDruggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe MoleculesMAPK-Activated Protein Kinases (MKs): Novel Insights and ChallengesATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour SuppressorThe Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1Crystal Structure of the Ca2+/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formationIdentification of a Novel Inhibitory Allosteric Site in p38αThe diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitorp38 MAP kinases in the heartThe intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor bindingChanges in protein structure at the interface accompanying complex formation.P38 mitogen-activated protein kinase activity is required during mitosis for timely satisfaction of the mitotic checkpoint but not for the fidelity of chromosome segregation.Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study.A model of a MAPK•substrate complex in an active conformation: a computational and experimental approachThe MK2/3 cascade regulates AMPAR trafficking and cognitive flexibilityEndothelial nitric oxide synthase is regulated by ERK phosphorylation at Ser602.Three-dimensional docking in the MAPK p38α.The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.Molecular mechanism by which palmitate inhibits PKR autophosphorylation.Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells.Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors.Insights from free-energy calculations: protein conformational equilibrium, driving forces, and ligand-binding modesp38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trialsp38 pathway kinases as anti-inflammatory drug targets.Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.Structural basis for the regulation of the mitogen-activated protein (MAP) kinase p38α by the dual specificity phosphatase 16 MAP kinase binding domain in solutionKinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression.PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries.Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinaseComparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.Low-molecular-weight MK2 inhibitors: a tough nut to crack!The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease.
P2860
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P2860
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@ast
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@en
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@nl
type
label
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@ast
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@en
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@nl
prefLabel
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@ast
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@en
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@nl
P2093
P2860
P356
P1476
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
@en
P2093
Andre White
Bennett T Farmer
Brian G Werneburg
Christopher A Pargellis
Joey M Studts
P2860
P304
P356
10.1073/PNAS.0701679104
P407
P577
2007-04-10T00:00:00Z