Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
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Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors.Global Conformational Dynamics of HIV-1 Reverse Transcriptase Bound to Non-Nucleoside Inhibitors.A cell-intrinsic inhibitor of HIV-1 reverse transcription in CD4(+) T cells from elite controllersThe Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutationsFitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1.Relationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.Structures of reverse transcriptase pre- and post-excision complexes shed new light on HIV-1 AZT resistanceAnalysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.Aptamers that recognize drug-resistant HIV-1 reverse transcriptaseSolution characterization of [methyl-(13)C]methionine HIV-1 reverse transcriptase by NMR spectroscopyEffects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.Winning the arms race by improving drug discovery against mutating targets.Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNStructural similarity-based predictions of protein interactions between HIV-1 and Homo sapiens.Chain-terminating dinucleoside tetraphosphates are substrates for DNA polymerization by human immunodeficiency virus type 1 reverse transcriptase with increased activity against thymidine analogue-resistant mutants.Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase.Homodimerization of the p51 subunit of HIV-1 reverse transcriptase.The interplay of structure and dynamics: insights from a survey of HIV-1 reverse transcriptase crystal structures.Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.Compensatory role of double mutation N348I/M184V on nevirapine binding landscape: insight from molecular dynamics simulation.Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC.Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.
P2860
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P2860
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
description
2002 nî lūn-bûn
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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Crystal Structures of Zidovudi ...... ons at Codons 41, 184, and 215
@nl
Crystal structures of Zidovudi ...... ns at codons 41, 184, and 215.
@ast
Crystal structures of Zidovudi ...... ns at codons 41, 184, and 215.
@en
type
label
Crystal Structures of Zidovudi ...... ons at Codons 41, 184, and 215
@nl
Crystal structures of Zidovudi ...... ns at codons 41, 184, and 215.
@ast
Crystal structures of Zidovudi ...... ns at codons 41, 184, and 215.
@en
prefLabel
Crystal Structures of Zidovudi ...... ons at Codons 41, 184, and 215
@nl
Crystal structures of Zidovudi ...... ns at codons 41, 184, and 215.
@ast
Crystal structures of Zidovudi ...... ns at codons 41, 184, and 215.
@en
P2093
P2860
P1433
P1476
Crystal structures of Zidovudi ...... ns at codons 41, 184, and 215.
@en
P2093
B A Larder
C E Nichols
D I Stuart
D K Stammers
J Lennerstrand
P P Chamberlain
P2860
P304
10015-10019
P356
10.1128/JVI.76.19.10015-10019.2002
P50
P577
2002-10-01T00:00:00Z