Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence
about
Inteins, introns, and homing endonucleases: recent revelations about the life cycle of parasitic genetic elementsDiscovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domainsStructural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factorI-ApeKI [corrected]: a novel intron-encoded LAGLIDADG homing endonuclease from the archaeon, Aeropyrum pernix K1Nature's recipe for splitting inteinsDNA dynamics and single-molecule biologyHoming endonucleases: DNA scissors on a missionNMR structure of a KlbA intein precursor fromMethanococcus jannaschiiCoevolution of a Homing Endonuclease and Its Host Target SequenceCrystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathwayCrystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineeringGeneration of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteinsStructural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional RegulatorEvolution of I-SceI Homing Endonucleases with Increased DNA Recognition Site SpecificityStructural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II of Pyrococcus abyssiMycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn(2+) and DNA-dependent ATPase activityBackbone assignments of mini-RecA intein with short native exteins and an active N-terminal catalytic cysteine.Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleasesComputer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences.Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.Sex-determination system in the diploid yeast Zygosaccharomyces sapaeA novel engineered meganuclease induces homologous recombination in yeast and mammalian cellsAsparagine peptide lyases: a seventh catalytic type of proteolytic enzymes.Analysis of the LAGLIDADG interface of the monomeric homing endonuclease I-DmoI.How the BfiI restriction enzyme uses one active site to cut two DNA strands.Structural stability and endonuclease activity of a PI-SceI GFP-fusion proteinMeganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy.Evolution of the MAT locus and its Ho endonuclease in yeast species.Engineering variants of the I-SceI homing endonuclease with strand-specific and site-specific DNA-nicking activity.Evolution of divergent DNA recognition specificities in VDE homing endonucleases from two yeast species.Characterization of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals a unique mode of DNA binding, helical distortion, and cleavage compared with a canonical LAGLIDADG homing endonucleaseProgrammable Genome Editing Tools and their Regulation for Efficient Genome Engineering.Homing endonucleases: from microbial genetic invaders to reagents for targeted DNA modification.Towards artificial metallonucleases for gene therapy: recent advances and new perspectives.DNA recognition by the homing endonuclease PI-SceI involves a divalent metal ion cofactor-induced conformational change.Homology modeling and mutational analysis of Ho endonuclease of yeast.Homing endonucleases from mobile group I introns: discovery to genome engineering.An archaeal homing endonuclease I-PogI cleaves at the insertion site of the neighboring intron, which has no nested open reading frame.Mutational analysis of active-site residues in the Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease: Asp(122) and Asp(193) are crucial to the double-stranded DNA cleavage activity whereas Asp(218) is not.In vitro analysis of the relationship between endonuclease and maturase activities in the bi-functional group I intron-encoded protein, I-AniI.
P2860
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P2860
Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
name
Crystal structure of the intei ...... nd to its recognition sequence
@ast
Crystal structure of the intei ...... nd to its recognition sequence
@en
Crystal structure of the intei ...... nd to its recognition sequence
@nl
type
label
Crystal structure of the intei ...... nd to its recognition sequence
@ast
Crystal structure of the intei ...... nd to its recognition sequence
@en
Crystal structure of the intei ...... nd to its recognition sequence
@nl
prefLabel
Crystal structure of the intei ...... nd to its recognition sequence
@ast
Crystal structure of the intei ...... nd to its recognition sequence
@en
Crystal structure of the intei ...... nd to its recognition sequence
@nl
P2093
P356
P1476
Crystal structure of the intei ...... nd to its recognition sequence
@en
P2093
Carmen M Moure
Florante A Quiocho
Frederick S Gimble
P2888
P304
P356
10.1038/NSB840
P407
P577
2002-10-01T00:00:00Z
P5875
P6179
1040183639