The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition
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Cocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions #Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpainsExpression of calpain-calpastatin system (CCS) member proteins in human lymphocytes of young and elderly individuals; pilot baseline data for the CALPACENT project.Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.Homology modeling study of bovine μ-calpain inhibitor-binding domains.Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells.The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.Calpain chronicle--an enzyme family under multidisciplinary characterizationCAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse modelGenome-wide association study identifies a possible susceptibility locus for endometrial cancerDecreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer.Structure-function relationships in calpains.Calpain research for drug discovery: challenges and potential.Small-angle X-ray scattering of calpain-5 reveals a highly open conformation among calpains.Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.Calpain-2 as a therapeutic target for acute neuronal injury.Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively.A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay.
P2860
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P2860
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The crystal structures of huma ...... of action and auto-inhibition
@ast
The crystal structures of huma ...... of action and auto-inhibition
@en
The crystal structures of huma ...... of action and auto-inhibition
@nl
type
label
The crystal structures of huma ...... of action and auto-inhibition
@ast
The crystal structures of huma ...... of action and auto-inhibition
@en
The crystal structures of huma ...... of action and auto-inhibition
@nl
prefLabel
The crystal structures of huma ...... of action and auto-inhibition
@ast
The crystal structures of huma ...... of action and auto-inhibition
@en
The crystal structures of huma ...... of action and auto-inhibition
@nl
P2093
P3181
P1476
The crystal structures of huma ...... of action and auto-inhibition
@en
P2093
Elena M Newman
Farrell Mackenzie
John R Walker
Patrick J Finerty
Tara L Davis
P304
P3181
P356
10.1016/J.JMB.2006.11.037
P407
P577
2007-02-09T00:00:00Z