Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator
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The path for metal complexes to a DNA targetA Bulky Rhodium Complex Bound to an Adenosine-Adenosine DNA Mismatch: General Architecture of the Metalloinsertion Binding ModeCrystal structure of Δ-[Ru(bpy)2dppz]2+ bound to mismatched DNA reveals side-by-side metalloinsertion and intercalationStructure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligandDouble threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine-thymine mismatchCrystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modesDelta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modesDifferential targeting of unpaired bases within duplex DNA by the natural compound clerocidin: a valuable tool to dissect DNA secondary structureLuminescent properties of ruthenium(II) complexes with sterically expansive ligands bound to DNA defects.An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency.A monofunctional platinum complex coordinated to a rhodium metalloinsertor selectively binds mismatched DNA in the minor groove.Targeting DNA Mismatches with Rhodium Metalloinsertors.Thymine dimer-induced structural changes to the DNA duplex examined with reactive probes (†).The phosphate clamp: a small and independent motif for nucleic acid backbone recognitionStructure-based DNA-targeting strategies with small molecule ligands for drug discovery.Targeting karyotypic complexity and chromosomal instability of cancer cells.Naphthyridine tetramer with a pre-organized structure for 1:1 binding to a CGG/CGG sequence.An omics perspective to the molecular mechanisms of anticancer metallo-drugs in the computational microscope era.Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA.Selective recognition of pyrimidine-pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalatorsMetallo-intercalators and metallo-insertorsCell-selective biological activity of rhodium metalloinsertors correlates with subcellular localizationRecognition of abasic sites and single base bulges in DNA by a metalloinsertorBinding of Ru(bpy)2(eilatin)2+ to matched and mismatched DNA.Insertion of a bulky rhodium complex into a DNA cytosine-cytosine mismatch: an NMR solution study.DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes.Gold(III) macrocycles: nucleotide-specific unconventional catalytic inhibitors of human topoisomerase I.Ruthenium(II) polypyridyl complexes and DNA--from structural probes to cellular imaging and therapeutics.Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules.Atomistic-level portrayal of drug-DNA Interplay: a history of courtships and meetings revealed by molecular simulations.DNA strand cleavage near a CC mismatch directed by a metalloinsertorLuminescence of [Ru(bpy)2(dppz)]2+ bound to RNA mismatches.Sensitivity of Ru(bpy)2dppz2+ luminescence to DNA defects.DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors.Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells.[Ru(Me4phen)2dppz](2+), a Light Switch for DNA MismatchesBinding of copper(II) polypyridyl complexes to DNA and consequences for DNA-based asymmetric catalysis.Biological effects of simple changes in functionality on rhodium metalloinsertors.Intercalation processes of copper complexes in DNA.Targeting abasic sites and single base bulges in DNA with metalloinsertors.
P2860
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P2860
Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator
description
2007 nî lūn-bûn
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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2007 թվականի հունվարին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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name
Insights into finding a mismat ...... ound by a rhodium intercalator
@ast
Insights into finding a mismat ...... ound by a rhodium intercalator
@en
Insights into finding a mismat ...... ound by a rhodium intercalator
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Insights into finding a mismat ...... ound by a rhodium intercalator
@ast
Insights into finding a mismat ...... ound by a rhodium intercalator
@en
Insights into finding a mismat ...... ound by a rhodium intercalator
@nl
prefLabel
Insights into finding a mismat ...... ound by a rhodium intercalator
@ast
Insights into finding a mismat ...... ound by a rhodium intercalator
@en
Insights into finding a mismat ...... ound by a rhodium intercalator
@nl
P2093
P2860
P3181
P356
P1476
Insights into finding a mismat ...... ound by a rhodium intercalator
@en
P2093
Jacqueline K Barton
Jens T Kaiser
Valérie C Pierre
P2860
P304
P3181
P356
10.1073/PNAS.0610170104
P407
P577
2007-01-09T00:00:00Z