The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics
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The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel DeactivationA molecular switch driving inactivation in the cardiac K+ channel HERGThe EGFP/hERG fusion protein alter the electrophysiological properties of hERG channels in HEK293 cells.Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channelsActivation of human ether-a-go-go related gene (hERG) potassium channels by small moleculesTwo four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study.Novel characteristics of a trafficking-defective G572R-hERG channel linked to hereditary long QT syndrome.The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations.Ion conduction through the hERG potassium channel.Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domainKinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1The hERG potassium channel as a therapeutic target.Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currentsInsights into hERG K+ channel structure and function from NMR studies.hERG quality control and the long QT syndrome.The hERG K(+) channel S4 domain L532P mutation: characterization at 37°CThe asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage-dependent inactivation.hERG ion channel pharmacology: cell membrane liposomes in porous-supported lipid bilayers compared with whole-cell patch-clamping.Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed.Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells.
P2860
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P2860
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics
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2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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The HERG K+ channel: progress ...... of its unusual gating kinetics
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The HERG K+ channel: progress ...... of its unusual gating kinetics
@en
The HERG K+ channel: progress ...... of its unusual gating kinetics
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The HERG K+ channel: progress ...... of its unusual gating kinetics
@ast
The HERG K+ channel: progress ...... of its unusual gating kinetics
@en
The HERG K+ channel: progress ...... of its unusual gating kinetics
@nl
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The HERG K+ channel: progress ...... of its unusual gating kinetics
@ast
The HERG K+ channel: progress ...... of its unusual gating kinetics
@en
The HERG K+ channel: progress ...... of its unusual gating kinetics
@nl
P2093
P1476
The HERG K+ channel: progress ...... of its unusual gating kinetics
@en
P2093
Allan M Torres
Jamie I Vandenberg
Philip W Kuchel
Terence J Campbell
P2888
P356
10.1007/S00249-003-0338-3
P577
2004-04-01T00:00:00Z
P5875
P6179
1051789791