The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation
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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channelStructure of the carboxy-terminal region of a KCNH channelStructural properties of PAS domains from the KCNH potassium channelsThe S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation GatingThe structural mechanism of KCNH-channel regulation by the eag domain.Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology DomainMolecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.An Interdomain KCNH2 Mutation Produces an Intermediate Long QT SyndromeRole of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channelsMultiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome.The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations.Demonstration of physical proximity between the N terminus and the S4-S5 linker of the human ether-a-go-go-related gene (hERG) potassium channelhERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: a possible mechanism for long QT syndrome.C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation.The amino-terminal helix modulates light-activated conformational changes in AsLOV2.Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channelsThe eag domain regulates hERG channel inactivation gating via a direct interaction.Investigating models of protein function and allostery with a widespread mutational analysis of a light-activated proteinDirect interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domainA functional Kv1.2-hERG chimaeric channel expressed in Pichia pastorisCytoplasmic domains and voltage-dependent potassium channel gating.HERG potassium channel regulation by the N-terminal eag domain.Insights into hERG K+ channel structure and function from NMR studies.Voltage-dependent gating of HERG potassium channels.The enigmatic cytoplasmic regions of KCNH channels.Getting to the heart of hERG K(+) channel gating.Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.Molecular Pathophysiology of Congenital Long QT Syndrome.Development of Safe Drugs: The hERG Challenge.Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome.Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels.Early LQT2 nonsense mutation generates N-terminally truncated hERG channels with altered gating properties by the reinitiation of translation.Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.¹H, ¹³C and ¹⁵N chemical shift assignments for the N-terminal PAS domain of the KCNH channel from zebrafish.Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains.Express with caution: Epitope tags and cDNA variants effects on hERG channel trafficking, half-life and function.
P2860
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P2860
The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation
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2011 nî lūn-bûn
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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@ast
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@en
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@nl
type
label
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@ast
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@en
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@nl
prefLabel
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@ast
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@en
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@nl
P2093
P2860
P50
P3181
P1433
P1476
The N–Terminal Tail of hERG Co ...... Regulates Channel Deactivation
@en
P2093
Daniela Stock
Mark J Hunter
Matthew D Perry
Philip W Kuchel
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0016191
P407
P577
2011-01-13T00:00:00Z