Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesStructural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteinsSH2B1beta adaptor is a key enhancer of RET tyrosine kinase signalingActivation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesKinase activation through dimerization by human SH2-BEnigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocationThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsA surface phospholipase is involved in the migration of plasmodium sporozoites through cellsStructural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligaseSmall-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptorStructural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14Structural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4The language of SH2 domain interactions defines phosphotyrosine-mediated signal transductionStructural basis for inhibition of the insulin receptor by the adaptor protein Grb14Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions.SH2B1 regulation of energy balance, body weight, and glucose metabolism.Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Structural basis for HNF-4alpha activation by ligand and coactivator binding.Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signalingHow IGF-1 activates its receptor.Grb10 and Grb14: enigmatic regulators of insulin action--and more?Molecular targets related to inflammation and insulin resistance and potential interventionsAdapter protein connections: the MRL and Grb7 protein families.Insulin signaling and the regulation of glucose transport.Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Receptor tyrosine kinases: mechanisms of activation and signaling.Oncogenic re-wiring of cellular signaling pathways.The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FDisruption of the SH2-B gene causes age-dependent insulin resistance and glucose intoleranceTyrosine phosphorylation: thirty years and counting.Identification of in vitro autophosphorylation sites and effects of phosphorylation on the Arabidopsis CRINKLY4 (ACR4) receptor-like kinase intracellular domain: insights into conformation, oligomerization, and activity.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Ste20-like kinase SLK, at the crossroads: a matter of life and deathMetabolic functions of glucocorticoid receptor in skeletal muscle.Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state
P2860
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P2860
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural basis for recruitme ...... the activated insulin receptor
@ast
Structural basis for recruitme ...... the activated insulin receptor
@en
Structural basis for recruitme ...... the activated insulin receptor
@nl
type
label
Structural basis for recruitme ...... the activated insulin receptor
@ast
Structural basis for recruitme ...... the activated insulin receptor
@en
Structural basis for recruitme ...... the activated insulin receptor
@nl
prefLabel
Structural basis for recruitme ...... the activated insulin receptor
@ast
Structural basis for recruitme ...... the activated insulin receptor
@en
Structural basis for recruitme ...... the activated insulin receptor
@nl
P2093
P1433
P1476
Structural basis for recruitme ...... the activated insulin receptor
@en
P2093
Rodolfo Ghirlando
P304
P356
10.1016/S1097-2765(03)00487-8
P577
2003-12-01T00:00:00Z