Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor - Test2 - elhamkhani - TriplyDB

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

http://www.wikidata.org/entity/Q27650906

about

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure A Highly Selective Dual Insulin Receptor (IR)/Insulin-like Growth Factor 1 Receptor (IGF-1R) Inhibitor Derived from an Extracellular Signal-regulated Kinase (ERK) Inhibitor IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases The complexity of the IGF1 gene splicing, posttranslational modification and bioactivity Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach Defining the pathway to insulin-like growth factor system targeting in cancer.Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo.How IGF-1 activates its receptor.Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth Virtual screening of specific insulin-like growth factor 1 receptor (IGF1R) inhibitors from the National Cancer Institute (NCI) molecular database Novel C6-substituted 1,3,4-oxadiazinones as potential anti-cancer agents.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review Molecular mechanisms of drug resistance in tyrosine kinases cAbl and cKit.The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism.Musk Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis.Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation.The human kinome and kinase inhibition.Improving methyl parathion hydrolase to enhance its chlorpyrifos-hydrolysing efficiency.A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms.The molecular basis of JAK/STAT inhibition by SOCS1.Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain.

P2860

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P2860

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

http://www.wikidata.org/entity/Q27650906

description

2008 nî lūn-bûn

@nan

2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@ast

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@en

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@nl

type

label

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@ast

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@en

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@nl

prefLabel

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@ast

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

@en

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

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The EMBO Journal

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Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

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Barbara P Craddock

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Jinhua Wu

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Kenneth W Foreman

http://www.w3.org/2001/XMLSchema#string

Mark J Mulvihill

http://www.w3.org/2001/XMLSchema#string

Qun-sheng Ji

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W Todd Miller

http://www.w3.org/2001/XMLSchema#string

Wanqing Li

http://www.w3.org/2001/XMLSchema#string

P2860

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites

Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

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1985-1994

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3159672

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10.1038/EMBOJ.2008.116

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14

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27

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Stevan R Hubbard

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2008-06-19T00:00:00Z

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5289198

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18566589

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phosphorylation

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2486273

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