Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa
about
Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29Expression Atlas of the Deubiquitinating Enzymes in the Adult Mouse Retina, Their Evolutionary Diversification and Phenotypic RolesCrystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutantsCrystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteinsStructure and function of an RNase H domain at the heart of the spliceosomeFunctional stabilization of an RNA recognition motif by a noncanonical N-terminal expansionStructural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2Mechanism for Aar2p function as a U5 snRNP assembly factorStructural and Thermodynamic Comparison of the Catalytic Domain of AMSH and AMSH-LP: Nearly Identical Fold but Different StabilityInsights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1Crystal structure of Prp8 reveals active site cavity of the spliceosomeStructural basis for dual roles of Aar2p in U5 snRNP assemblyCrystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding proteinStructural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteThe crystal structure of the MPN domain from the COP9 signalosome subunit CSN6Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and ProductInhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeastPrp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Progressive Hearing Loss in Mice Carrying a Mutation in Usp53.Spliceosome Structure and FunctionMutations in spliceosomal proteins and retina degenerationCytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptaseRibonucleoprotein multimers and their functions.Structure of mammalian eIF3 in the context of the 43S preinitiation complex.Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cellsInhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cellsIdentification of Novel and Recurrent Disease-Causing Mutations in Retinal Dystrophies Using Whole Exome Sequencing (WES): Benefits and Limitations.Detailed close-ups and the big picture of spliceosomesSuppressors of the cdc-25.1(gf)-associated intestinal hyperplasia reveal important maternal roles for prp-8 and a subset of splicing factors in C. elegans.Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivityATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.A role for ubiquitin in the spliceosome assembly pathway.Mutations in the small nuclear riboprotein 200 kDa gene (SNRNP200) cause 1.6% of autosomal dominant retinitis pigmentosaPolyubiquitin binding and disassembly by deubiquitinating enzymes.Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.
P2860
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P2860
Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa
description
2007 nî lūn-bûn
@nan
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@ast
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@en
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@nl
type
label
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@ast
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@en
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@nl
prefLabel
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@ast
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@en
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@nl
P50
P3181
P1433
P1476
Structure of a multipartite pr ...... s link to retinitis pigmentosa
@en
P2093
Sunbin Liu
Vladimir Pena
P304
P3181
P356
10.1016/J.MOLCEL.2007.01.023
P577
2007-02-23T00:00:00Z