ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.
about
Cwc24p is a general Saccharomyces cerevisiae splicing factor required for the stable U2 snRNP binding to primary transcriptsRNA helicases at work: binding and rearrangingThe organization and contribution of helicases to RNA splicingFunctional roles of DExD/H-box RNA helicases in Pre-mRNA splicingRNA helicases in splicingThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2Mechanism for Aar2p function as a U5 snRNP assembly factorStructural basis for dual roles of Aar2p in U5 snRNP assemblyStructural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteThe crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicingInhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8Cofactor-dependent specificity of a DEAD-box protein.Splicing proofreading at 5' splice sites by ATPase Prp28p.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Spliceosome Structure and FunctionFrom the ribosome to the spliceosome and back again.Mutations in spliceosomal proteins and retina degenerationSNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa.Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cellsA missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosaFunctional complexity and regulation through RNA dynamicsBRR2a Affects Flowering Time via FLC SplicingIdentification of Novel and Recurrent Disease-Causing Mutations in Retinal Dystrophies Using Whole Exome Sequencing (WES): Benefits and Limitations.Functional roles of protein splicing factors.Mutations in Splicing Factor Genes Are a Major Cause of Autosomal Dominant Retinitis Pigmentosa in Belgian FamiliesSpliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!Link of NTR-mediated spliceosome disassembly with DEAH-box ATPases Prp2, Prp16, and Prp22.Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA.The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicingRetinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivitySubstrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs.Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis.The spliceosomal proteome: at the heart of the largest cellular ribonucleoprotein machine.Structural studies of the spliceosome: zooming into the heart of the machine.Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.A snRNP's ordered path to maturity.Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.
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P2860
ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
ATP-dependent unwinding of U4/ ...... quires the C terminus of Prp8.
@en
ATP-dependent unwinding of U4/ ...... quires the C terminus of Prp8.
@nl
type
label
ATP-dependent unwinding of U4/ ...... quires the C terminus of Prp8.
@en
ATP-dependent unwinding of U4/ ...... quires the C terminus of Prp8.
@nl
prefLabel
ATP-dependent unwinding of U4/ ...... quires the C terminus of Prp8.
@en
ATP-dependent unwinding of U4/ ...... quires the C terminus of Prp8.
@nl
P2093
P2860
P356
P1476
ATP-dependent unwinding of U4/ ...... quires the C terminus of Prp8.
@en
P2093
Alan K Kutach
Christine Guthrie
Corina Maeder
P2860
P2888
P356
10.1038/NSMB.1535
P577
2008-12-21T00:00:00Z
P5875
P6179
1034636511