Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate
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Drugging topoisomerases: lessons and challengesStructural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cellsMethanosarcina acetivorans C2A topoisomerase IIIα, an archaeal enzyme with promiscuity in divalent cation dependence.Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V.Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I.Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways.Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.Structural studies of type I topoisomerases.Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.Topoisomerase as target for antibacterial and anticancer drug discovery.Studies of bacterial topoisomerases I and III at the single-molecule level.Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factorEssential functions of C terminus of Drosophila Topoisomerase IIIα in double holliday junction dissolutionAn orthogonal single-molecule experiment reveals multiple-attempt dynamics of type IA topoisomerases.Carboxyl terminal domain basic amino acids of mycobacterial topoisomerase I bind DNA to promote strand passage.Type IA DNA Topoisomerases: A Universal Core and Multiple Activities.Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha.Inhibition of type IA topoisomerase by a monoclonal antibody through perturbation of DNA cleavage-religation equilibrium.
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P2860
Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate
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2007 nî lūn-bûn
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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2007 թվականի ապրիլին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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name
Structural Studies of E. coli ...... NA Conformational Intermediate
@ast
Structural Studies of E. coli ...... NA Conformational Intermediate
@en
Structural Studies of E. coli ...... NA Conformational Intermediate
@nl
type
label
Structural Studies of E. coli ...... NA Conformational Intermediate
@ast
Structural Studies of E. coli ...... NA Conformational Intermediate
@en
Structural Studies of E. coli ...... NA Conformational Intermediate
@nl
prefLabel
Structural Studies of E. coli ...... NA Conformational Intermediate
@ast
Structural Studies of E. coli ...... NA Conformational Intermediate
@en
Structural Studies of E. coli ...... NA Conformational Intermediate
@nl
P2093
P2860
P1476
Structural Studies of E. coli ...... NA Conformational Intermediate
@en
P2093
Alfonso Mondragón
Anita Changela
Russell J DiGate
P2860
P304
P356
10.1016/J.JMB.2007.01.065
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P577
2007-04-20T00:00:00Z