Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
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Arginine Demethylation of G3BP1 Promotes Stress Granule AssemblySynthetic lethality: emerging targets and opportunities in melanoma.Continuous Fluorescence Assays for Reactions Involving AdenineHeat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase.MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Genetic drivers of vulnerability and resistance in relapsed acute lymphoblastic leukemia.Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia.Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cellsMarked for death: targeting epigenetic changes in cancer.Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.Therapeutic targeting of splicing in cancer.Metabolic interactions with cancer epigenetics.Metabolic control of epigenetics in cancer.The story of protein arginine methylation: characterization, regulation, and function.Understanding the Intersections between Metabolism and Cancer Biology.Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.Novel insights into mesothelioma biology and implications for therapy.Is There a Therapeutic Window for Metabolism-Based Cancer Therapies?FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion.ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer.The Transition-State Structure for Human MAT2A from Isotope Effects.Clinical study of genomic drivers in pancreatic ductal adenocarcinoma.SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.Deletion and downregulation of MTAP contribute to the motility of esophageal squamous carcinoma cells.mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease.WD40 repeat domain proteins: a novel target class?PRMT5 determines the sensitivity to chemotherapeutics by governing stemness in breast cancer.Targeting protein arginine methyltransferase 5 in disease.The impact of cellular metabolism on chromatin dynamics and epigenetics.Targeting Metabolism for Cancer Therapy.Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.Emerging Opportunities for Target Discovery in Rare Cancers.Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism.The Structure and Function of the PRMT5:MEP50 Complex.Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.
P2860
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P2860
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
description
2016 nî lūn-bûn
@nan
2016 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մարտին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@ast
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@en
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@nl
type
label
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@ast
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@en
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@nl
prefLabel
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@ast
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@en
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@nl
P2093
P2860
P3181
P356
P1433
P1476
Disordered methionine metaboli ...... s leads to dependence on PRMT5
@en
P2093
Albert Lai
Alberto C Vitari
Antoine deWeck
Bing Zheng
Craig Mickanin
D Randal Kipp
David A Ruddy
David Ciccone
E Robert McDonald
Elizabeth R Sprague
P2860
P304
P3181
P356
10.1126/SCIENCE.AAD5944
P407
P50
P577
2016-02-11T00:00:00Z