Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity
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Structural biology and chemistry of protein arginine methyltransferasesDisordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma bruceiStructural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active siteThe PRMT5 arginine methyltransferase: many roles in development, cancer and beyondStructural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.Readers of histone methylarginine marks.PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferaseMethylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene ExpressionPrion Protein-Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering.JMJD6 regulates ERα methylation on arginine.KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation.An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.Inhibitors of Protein Methyltransferases and Demethylases.Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations.A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.Discovery of a Dual PRMT5-PRMT7 Inhibitor.Structural basis of arginine asymmetrical dimethylation by PRMT6.SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.Middle-Down and Chemical Proteomic Approaches to Reveal Histone H4 Modification Dynamics in Cell Cycle: Label-Free Semi-Quantification of Histone Tail Peptide Modifications Including Phosphorylation and Highly Sensitive Capture of Histone PTM BindinMEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases.The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release.Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression.Intricate Effects of α-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4.Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2.Cryo-electron microscopy structure of a human PRMT5:MEP50 complex.
P2860
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P2860
Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity
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2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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Structure of the Arginine Meth ...... nism for Substrate Specificity
@ast
Structure of the Arginine Meth ...... nism for Substrate Specificity
@en
Structure of the Arginine Meth ...... nism for Substrate Specificity
@nl
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label
Structure of the Arginine Meth ...... nism for Substrate Specificity
@ast
Structure of the Arginine Meth ...... nism for Substrate Specificity
@en
Structure of the Arginine Meth ...... nism for Substrate Specificity
@nl
prefLabel
Structure of the Arginine Meth ...... nism for Substrate Specificity
@ast
Structure of the Arginine Meth ...... nism for Substrate Specificity
@en
Structure of the Arginine Meth ...... nism for Substrate Specificity
@nl
P2093
P2860
P3181
P1433
P1476
Structure of the Arginine Meth ...... nism for Substrate Specificity
@en
P2093
Carola Wilczek
David Shechter
Janina Seznec
Jeffrey B Bonanno
Lester G Carter
Man K Chan
Meng-Chiao Ho
Michael Brenowitz
P Rajesh Kumar
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0057008
P407
P577
2013-01-01T00:00:00Z