Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding
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Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic StudiesCrystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGTHow to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylaseFrom lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersHot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzymeCharacterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structureStructure and function of preQ1 riboswitchesLigand pose and orientational sampling in molecular dockingIdentification of Plasmodium falciparum apicoplast-targeted tRNA-guanine transglycosylase and its potential inhibitors using comparative genomics, molecular modelling, docking and simulation studiesSoaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionPlant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family.Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discoveryThe queuine micronutrient: charting a course from microbe to man.Site-specific modification of Shigella flexneri virF mRNA by tRNA-guanine transglycosylase in vitroA medicinal chemist's guide to molecular interactionsCross-Talk between Dnmt2-Dependent tRNA Methylation and Queuosine Modification.Structure and function of noncanonical nucleobases.Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases.High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT).
P2860
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P2860
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding
description
2007 nî lūn-bûn
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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@ast
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@en
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@nl
type
label
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@ast
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@en
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@nl
prefLabel
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@ast
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@en
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@nl
P2093
P50
P1476
Crystal structures of tRNA-gua ...... rmation upon substrate binding
@en
P2093
Andreas Heine
Bernhard Stengl
Emmanuel A Meyer
P304
P356
10.1016/J.JMB.2007.04.008
P407
P577
2007-07-13T00:00:00Z