How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase

How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase

Item
http://www.wikidata.org/entity/Q27658079
Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural waterInvestigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as InhibitorFrom lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clustersReplacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibitionCurrent progress in Structure-Based Rational Drug Design marks a new mindset in drug discoveryHot spot analysis for driving the development of hits into leads in fragment-based drug discovery.A medicinal chemist's guide to molecular interactionsAromatic rings in chemical and biological recognition: energetics and structures.Molecular recognition in chemical and biological systems.Free enthalpies of replacing water molecules in protein binding pockets
P2860

How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase

Item
http://www.wikidata.org/entity/Q27658079
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
How to replace the residual so ...... tRNA-guanine transglycosylase
@ast
How to replace the residual so ...... tRNA-guanine transglycosylase
@en
How to replace the residual so ...... tRNA-guanine transglycosylase
@nl
type
label
How to replace the residual so ...... tRNA-guanine transglycosylase
@ast
How to replace the residual so ...... tRNA-guanine transglycosylase
@en
How to replace the residual so ...... tRNA-guanine transglycosylase
@nl
prefLabel
How to replace the residual so ...... tRNA-guanine transglycosylase
@ast
How to replace the residual so ...... tRNA-guanine transglycosylase
@en
How to replace the residual so ...... tRNA-guanine transglycosylase
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
How to replace the residual so ...... tRNA-guanine transglycosylase
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698