Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities
about
Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease familyOptimizing pH Response of Affinity between Protein G and IgG Fc: HOW ELECTROSTATIC MODULATIONS AFFECT PROTEIN-PROTEIN INTERACTIONSStructural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein Subunit MutantsComputational Design of the Sequence and Structure of a Protein-Binding PeptideCrystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from GαiAffinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPsCoupling Protein Side-Chain and Backbone Flexibility Improves the Re-design of Protein-Ligand SpecificityTargeting the SH3 domain of human osteoclast-stimulating factor with rationally designed peptoid inhibitors.Structure-Based Identification, Characterization, and Disruption of Human Securin-Binding SH3 Domains in Lung Cancer.Designing specific protein-protein interactions using computation, experimental library screening, or integrated methodsA point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamicsConformational stability as a design target to control protein aggregation.Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.Identification of structural mechanisms of HIV-1 protease specificity using computational peptide docking: implications for drug resistance.Predicting changes in protein thermostability brought about by single- or multi-site mutationsComputationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).The protein-protein interface evolution acts in a similar way to antibody affinity maturation.Computational and experimental approaches to reveal the effects of single nucleotide polymorphisms with respect to disease diagnosticsDevelopment of inhibitors of heterotrimeric Gαi subunitsAnchored design of protein-protein interfaces.Design and directed evolution of a dideoxy purine nucleoside phosphorylase.Computational design of second-site suppressor mutations at protein-protein interfacesEvolution: a guide to perturb protein function and networksIdentification of interacting hot spots in the beta3 integrin stalk using comprehensive interface designComputational protein design suggests that human PCNA-partner interactions are not optimized for affinity.Computational design of affinity and specificity at protein-protein interfacesThe scoring of poses in protein-protein docking: current capabilities and future directionsApplying physics-based scoring to calculate free energies of binding for single amino acid mutations in protein-protein complexesHow structure defines affinity in protein-protein interactions.Characterizing informative sequence descriptors and predicting binding affinities of heterodimeric protein complexes.Combined Antiviral Therapy Using Designed Molecular Scaffolds Targeting Two Distinct Viral Functions, HIV-1 Genome Integration and Capsid AssemblyMode of interaction of the Gαo subunit of heterotrimeric G proteins with the GoLoco1 motif of Drosophila Pins is determined by guanine nucleotides.Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface.Computer-aided design of functional protein interactions.An improved Protein G with higher affinity for human/rabbit IgG Fc domains exploiting a computationally designed polar network.A simple recipe for the non-expert bioinformaticist for building experimentally-testable hypotheses for proteins with no known homologs.Predicting affinity- and specificity-enhancing mutations at protein-protein interfaces.Structure and function of glycosylated tandem repeats from Candida albicans Als adhesins.Triathlon for energy functions: who is the winner for design of protein-protein interactions?GoLoco motif proteins binding to Galpha(i1): insights from molecular simulations.
P2860
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P2860
Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@ast
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@en
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@nl
type
label
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@ast
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@en
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@nl
prefLabel
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@ast
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@en
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@nl
P2093
P2860
P1476
Structure-based Protocol for I ...... ein–Protein Binding Affinities
@en
P2093
Carrie Purbeck
David P Siderovski
Deanne W Sammond
Randall J Kimple
Ziad M Eletr
P2860
P304
P356
10.1016/J.JMB.2007.05.096
P407
P577
2007-08-31T00:00:00Z