Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

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http://www.wikidata.org/entity/Q27649443
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsBACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseExploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).Developing β-secretase inhibitors for treatment of Alzheimer's disease.beta-Secretase as a therapeutic target for Alzheimer's disease.Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).Recent progress in the drug discovery of non-peptidic BACE1 inhibitors.Advances in the identification of β-secretase inhibitors.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.New directions for protease inhibitors directed drug discovery.Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease.Synthesis of amino heterocycle aspartyl protease inhibitors.High throughput virtual screening and E-pharmacophore filtering in the discovery of new BACE-1 inhibitors.Investigation of naphthofuran moiety as potential dual inhibitor against BACE-1 and GSK-3β: molecular dynamics simulations, binding energy, and network analysis to identify first-in-class dual inhibitors against Alzheimer's disease.
P2860

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets

Item
http://www.wikidata.org/entity/Q27649443
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@ast
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@en
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@nl
type
label
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@ast
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@en
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@nl
prefLabel
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@ast
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@en
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Acylguanidine inhibitors of be ...... d S3 substrate binding pockets
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P2093
P304
P31
P356
10.1016/J.BMCL.2007.12.010
P407
P433
P478
P577
P698
P921