Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate
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Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosisBiochemical and Structural Characterization of Mycobacterium tuberculosis β-Lactamase with the Carbapenems Ertapenem and DoripenemStructures of the Michaelis Complex (1.2 Å) and the Covalent Acyl Intermediate (2.0 Å) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis β-Lactamase K73A and E166A Mutants,Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosisNXL104 Irreversibly Inhibits the β-Lactamase from Mycobacterium tuberculosisCan Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis -Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of -Lactam- -Lactamase Inhibitor CombinationsKinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the β-Lactamase from Mycobacterium tuberculosisStrategies for discovering and derisking covalent, irreversible enzyme inhibitors.The chemical biology of new drugs in the development for tuberculosis.The enzymes of β-lactam biosynthesis.Combinatorial active-site variants confer sustained clavulanate resistance in BlaC β-lactamase from Mycobacterium tuberculosis.Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif.Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.Carbapenems and Rifampin Exhibit Synergy against Mycobacterium tuberculosis and Mycobacterium abscessus.Structural enzymology using X-ray free electron lasers.In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.Kinetic characterization of hydrolysis of nitrocefin, cefoxitin, and meropenem by β-lactamase from Mycobacterium tuberculosis.Reappraising the use of β-lactams to treat tuberculosis.Advances In Mycobacterium Tuberculosis Therapeutics Discovery Utlizing Structural Biology.The role of IgE recognition in allergic reactions to amoxicillin and clavulanic acid.β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam.Meropenem-clavulanic acid has high in vitro activity against multidrug-resistant Mycobacterium tuberculosis.Phosphate Promotes the Recovery of Mycobacterium tuberculosis β-Lactamase from Clavulanic Acid Inhibition.Watching Proteins Function with Time-resolved X-ray Crystallography.Inhibition of β-lactamases of mycobacteria by avibactam and clavulanate.Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.
P2860
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P2860
Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure of the covalent addu ...... beta-lactamase and clavulanate
@ast
Structure of the covalent addu ...... beta-lactamase and clavulanate
@en
Structure of the covalent addu ...... beta-lactamase and clavulanate
@nl
type
label
Structure of the covalent addu ...... beta-lactamase and clavulanate
@ast
Structure of the covalent addu ...... beta-lactamase and clavulanate
@en
Structure of the covalent addu ...... beta-lactamase and clavulanate
@nl
prefLabel
Structure of the covalent addu ...... beta-lactamase and clavulanate
@ast
Structure of the covalent addu ...... beta-lactamase and clavulanate
@en
Structure of the covalent addu ...... beta-lactamase and clavulanate
@nl
P2093
P356
P1433
P1476
Structure of the covalent addu ...... beta-lactamase and clavulanate
@en
P2093
Jean-Emmanuel Hugonnet
John S Blanchard
Lee W Tremblay
P304
P356
10.1021/BI8001055
P407
P577
2008-05-13T00:00:00Z