Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †
about
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisIodine Atoms: A New Molecular Feature for the Design of Potent Transthyretin Fibrillogenesis InhibitorsToward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and CytotoxicityChemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasmaPotent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte ProteotoxicityAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateTafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascadeBifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensorsFluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learnStilbene Vinyl Sulfonamides as Fluorogenic Sensors of and Traceless Covalent Kinetic Stabilizers of Transthyretin That Prevent AmyloidogenesisUnderstanding the microscopic binding mechanism of hydroxylated and sulfated polybrominated diphenyl ethers with transthyretin by molecular docking, molecular dynamics simulations and binding free energy calculations.Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methodsFrom protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidosesA stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate.A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs.Does transthyretin function as one of contributors for preeclampsia?Enhancing bottom-up and top-down proteomic measurements with ion mobility separationsRepositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors.Transthyretin: the servant of many masters.Inhibition of human transthyretin aggregation by non-steroidal anti-inflammatory compounds: a structural and thermodynamic analysisA current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.Lysine-Targeting Covalent Inhibitors.Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.Current and future treatment of amyloid diseases.Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.Stabilization of protein-protein interactions in drug discovery.Structure-behavior study of a family of "hybrid cyanine" dyes which exhibit inverted solvatochromism.Understanding and Ameliorating the TTR Amyloidoses
P2860
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P2860
Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
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2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Toward Optimization of the Lin ...... mical and Structural Studies †
@ast
Toward Optimization of the Lin ...... mical and Structural Studies †
@en
Toward Optimization of the Lin ...... mical and Structural Studies †
@nl
type
label
Toward Optimization of the Lin ...... mical and Structural Studies †
@ast
Toward Optimization of the Lin ...... mical and Structural Studies †
@en
Toward Optimization of the Lin ...... mical and Structural Studies †
@nl
prefLabel
Toward Optimization of the Lin ...... mical and Structural Studies †
@ast
Toward Optimization of the Lin ...... mical and Structural Studies †
@en
Toward Optimization of the Lin ...... mical and Structural Studies †
@nl
P2860
P356
P1476
Toward Optimization of the Lin ...... mical and Structural Studies †
@en
P2093
Stephen Connelly
Steven M Johnson
P2860
P304
P356
10.1021/JM800435S
P407
P577
2008-10-23T00:00:00Z