Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †
about
Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosisNovel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural AnalysisA Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and CytotoxicityCrystallographic Study of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity between Two Thyroxine Binding SitesAromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent ConjugateBifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensorsFluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learnStilbene Vinyl Sulfonamides as Fluorogenic Sensors of and Traceless Covalent Kinetic Stabilizers of Transthyretin That Prevent AmyloidogenesisThe flavonoid luteolin, but not luteolin-7-O-glucoside, prevents a transthyretin mediated toxic responseTetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin TetramerComparison of helical scan and standard rotation methods in single-crystal X-ray data collection strategies.Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methodsStructure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidosesA stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate.A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.Does transthyretin function as one of contributors for preeclampsia?Identification of Transthyretin Fibril Formation Inhibitors Using Structure-Based Virtual Screening.Transthyretin: the servant of many masters.A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.Current and future treatment of amyloid diseases.A Facile Synthesis of Quinazolin-4(3H )-ones via Copper-Catalyzed One-Pot, Three-Component Tandem ReactionTafamidis (Vyndaqel): A Light for FAP Patients
P2860
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P2860
Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Toward Optimization of the Sec ...... mical and Structural Studies †
@ast
Toward Optimization of the Sec ...... mical and Structural Studies †
@en
Toward Optimization of the Sec ...... mical and Structural Studies †
@nl
type
label
Toward Optimization of the Sec ...... mical and Structural Studies †
@ast
Toward Optimization of the Sec ...... mical and Structural Studies †
@en
Toward Optimization of the Sec ...... mical and Structural Studies †
@nl
prefLabel
Toward Optimization of the Sec ...... mical and Structural Studies †
@ast
Toward Optimization of the Sec ...... mical and Structural Studies †
@en
Toward Optimization of the Sec ...... mical and Structural Studies †
@nl
P2860
P3181
P356
P1476
Toward Optimization of the Sec ...... mical and Structural Studies †
@en
P2093
Stephen Connelly
Steven M Johnson
P2860
P304
P3181
P356
10.1021/JM801347S
P407
P577
2009-02-26T00:00:00Z