Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
about
Interference of bacterial cell-to-cell communication: a new concept of antimicrobial chemotherapy breaks antibiotic resistanceGenetic control of bacterial biofilmsBiologically inspired strategies for combating bacterial biofilmsEnzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidaseMethylthioinosine Phosphorylase from Pseudomonas aeruginosa . Structure and Annotation of a Novel Enzyme in Quorum SensingSmall-molecule inhibitor binding to an N-acyl-homoserine lactone synthaseA Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pyloriMethylthioadenosine Deaminase in an Alternative Quorum Sensing Pathway in Pseudomonas aeruginosaSalmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State AnalogsStructural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway.Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimesSmall molecule control of bacterial biofilmsTransition StatesActive site and remote contributions to catalysis in methylthioadenosine nucleosidases.Enzymatic transition states and dynamic motion in barrier crossing.Fluorescence imaging of cellular metabolites with RNA.Enzyme homologues have distinct reaction paths through their transition states.Continuous Fluorescence Assays for Reactions Involving AdenineSinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth.Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism.S-aryl-L-cysteine sulphoxides and related organosulphur compounds alter oral biofilm development and AI-2-based cell-cell communication.Role of methylthioadenosine/S-adenosylhomocysteine nucleosidase in Vibrio cholerae cellular communication and biofilm development.Living in the matrix: assembly and control of Vibrio cholerae biofilms.Transition States and transition state analogue interactions with enzymes.Tight binding enantiomers of pre-clinical drug candidates.Exploiting quorum sensing to confuse bacterial pathogens.Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylaseDevelopment of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens.Conformational freedom in tight binding enzymatic transition-state analogues.Quorum sensing signal-response systems in Gram-negative bacteria.Transition States, analogues, and drug development.Quorum sensing inhibitors: a patent review.Small molecule inhibitors of AI-2 signaling in bacteria: state-of-the-art and future perspectives for anti-quorum sensing agents.Novel approaches for the design and discovery of quorum-sensing inhibitors.Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase.Chemical probes of quorum sensing: from compound development to biological discoveryStrategies for Biofilm Inhibition and Virulence Attenuation of Foodborne Pathogen-Escherichia coli O157:H7.Quorum sensing protects bacterial co-operation from exploitation by cheats.Molecular dynamics study of the effect of active site protonation on Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry.
P2860
Q21131123-BA074AA1-FBA6-4335-8F32-5B655B48A455Q26796226-09CBE730-FF9A-450C-A768-C7592E3F0681Q27006003-0B56150E-B2DA-4B81-BD42-379356DE2DD9Q27665126-F94AF32E-4EAB-47B2-BA96-363A44C51B0DQ27666427-9CEB5B4A-AF82-4A72-9146-A0B9C25ED921Q27670682-B420BB51-7C57-46B4-8BEC-3F3F535C28C0Q27671530-E67285CE-E7B0-4D82-A37F-B6B6B0E24439Q27674382-0FB3C095-AF89-4267-94A2-D7E1D2107EE2Q27678174-263AFA23-9F2B-4C99-B89F-07405A5580E0Q27925199-A8827E34-29E6-4A56-B18F-3C872FEDAC81Q28240827-DA4B4E53-2574-4170-9ABB-8933B85D0EC9Q28269575-FEF86639-BC26-4E10-979A-2C2326339247Q28749913-37883907-35AB-4EDB-8629-7FDC16220640Q30373000-92C5A593-7C7B-43D6-A9DD-16E185672992Q30494227-D432929C-EB74-4EBA-A7C5-D49BF1051368Q30510279-4EBDA541-2D11-4E81-A010-B8E379B24AC6Q30635744-38DA4B91-9A78-4FF2-9550-1505BF8D93D4Q33698415-D619FF68-1455-4C58-AF80-D820720E812AQ33891303-EFDE0B75-E5D7-406D-BDFC-06D3727CBF0DQ34672769-CDC29127-D4C9-4184-9241-B45064342BABQ35216782-776D7522-1DC8-4E4C-BCE3-8336B9A0DC29Q35588921-CE2582CB-7F9C-47EC-B89E-5271008BC385Q35624604-EACEBE03-41CD-41B5-BAE1-CF374DC45B8AQ35786344-ED81B559-09F0-42E1-9758-5D5B2B560CFFQ36052612-A3FC59D5-70D0-4DB2-8104-E3A9D8C7488CQ36667376-E36FC2DD-AAD2-4F7E-8368-F8EE02C759E7Q37091234-E40AD1DA-8FDF-437F-B3C6-C0029849C108Q37139191-4F439507-750E-4C45-B085-DC81F60EC34AQ37206494-7A6F59BA-6A96-4F63-9FE9-99353C1A2E98Q37324474-7AAEBAE8-0B65-44A1-8D85-F1EF75E974BDQ38069211-6BAB20B2-162C-4879-986C-6D089FB09C49Q38090644-6C900677-07B5-4E39-A270-F1FE58B5D3BEQ38133222-40EF1FF5-DA57-45EF-8E0F-B91644244ADBQ38193593-E0BFA665-F645-46AE-9650-B53288E4BD05Q38632726-E9B42DE5-5FD0-4269-A150-9C4BA3FF9D58Q38857135-738A2BBF-821C-4A9F-B9FB-CDD81C8D76A7Q39458640-7FEED9BC-9FF8-45FC-B222-F4908E3DAFB2Q40129838-2D4FBE67-0BF7-42BB-8955-A8D9A75C0FF4Q40646291-77FCE300-3CB3-490C-827F-8DE74527FB6AQ40736183-ACB4703B-8766-4FA0-97A3-E53551F6DACB
P2860
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
@ast
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
@en
Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing
@nl
type
label
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
@ast
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
@en
Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing
@nl
prefLabel
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
@ast
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
@en
Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing
@nl
P2093
P2860
P356
P1476
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
@en
P2093
Agnes Rinaldo-Matthis
Jemy A Gutierrez
Meng-Chiao Ho
Steven C Almo
Tamara Crowder
Vern L Schramm
P2860
P2888
P304
P356
10.1038/NCHEMBIO.153
P577
2009-03-08T00:00:00Z
P5875
P6179
1033822706