The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase
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Somatic DNA mutation analysis in targeted therapy of solid tumoursStructure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3βStructurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase InhibitorsIdentification of a Novel Family of BRAF V600E InhibitorsAn Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine TriphosphataseMutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanismsHydrogen bonding and anticancer properties of water-soluble chiral p-cymene Ru(II) compounds with amino-oxime ligandsMolecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.In vitro and in vivo evaluation of water-soluble iminophosphorane ruthenium(II) compounds. A potential chemotherapeutic agent for triple negative breast cancerOrganometallic anticancer compoundsEffects of BRAF mutations and BRAF inhibition on immune responses to melanomaDevelopment of organometallic S6K1 inhibitors.Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimizationAnticancer metallodrug research analytically painting the "omics" picture--current developments and future trends.Vemurafenib in melanoma.In silico identification of novel kinase inhibitors by targeting B-Raf(v660e) from natural products database.Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system.Development of the first model of a phosphorylated, ATP/Mg2+-containing B-Raf monomer by molecular dynamics simulations: a tool for structure-based design.Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-RafV600E inhibitors.Assessing protein-ligand docking for the binding of organometallic compounds to proteins.Metal complexes as "protein surface mimetics".Targeted treatment for melanoma.The Anticancer Activities of Some Nitrogen Donor Ligands Containing bis-Pyrazole, Bipyridine, and Phenanthroline Moiety Using Docking Methods.
P2860
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P2860
The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@ast
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@en
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@nl
type
label
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@ast
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@en
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@nl
prefLabel
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@ast
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@en
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@nl
P2093
P2860
P356
P1433
P1476
The Crystal Structure of BRAF ...... an Active Form of BRAF Kinase
@en
P2093
Craig Streu
Howard Bregman
Nicholas Pagano
P2860
P304
P356
10.1021/BI802067U
P407
P577
2009-06-16T00:00:00Z