Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors - Test2 - elhamkhani - TriplyDB

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

http://www.wikidata.org/entity/Q27667351

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Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor PIM1 kinase as a target for cancer therapy Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.Rhenium Complexes with Red-Light-Induced Anticancer Activity.Chiral-at-metal complexes and their catalytic applications in organic synthesis.A metal-based inhibitor of NEDD8-activating enzyme.Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties.Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors.Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models Rhenium complexes with visible-light-induced anticancer activity.Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo.PIM kinases as therapeutic targets against advanced melanoma.Targeted therapy vs. DNA-adduct formation-guided design: thoughts about the future of metal-based anticancer drugs.Organometallic compounds: an opportunity for chemical biology?Insights from Pim1 structure for anti-cancer drug design.Anticancer metallodrug research analytically painting the "omics" picture--current developments and future trends.Recent advances in the development of p21-activated kinase inhibitors RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.P21 activated kinases: structure, regulation, and functions.Metallomics insights into the programmed cell death induced by metal-based anticancer compounds.Molecular determinants of acute kidney injury.Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies.Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy.Pharmacophore-based screening and drug repurposing exemplified on glycogen synthase kinase-3 inhibitors.Phenanthroline ligands are biologically more active than their corresponding ruthenium(II) arene complexes.Ruthenium-Arene-β-Carboline Complexes as Potent Inhibitors of Cyclin-Dependent Kinase 1: Synthesis, Characterization and Anticancer Mechanism Studies.Exploiting Octahedral Stereocenters: From Enzyme Inhibition to Asymmetric Photoredox Catalysis.Combination of metallomics and proteomics to study the effects of the metallodrug RAPTA-T on human cancer cells.The [(Cp)M(CO)(3)] (M=Re, (99m)Tc) building block for imaging agents and bioinorganic probes: perspectives and limitations.The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials.Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.An iridium(iii)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent.Metal coordination study at Ag and Cd sites in crown thioether complexes through DFT calculations and hyperfine parameters.Prediction of kinase-inhibitor binding affinity using energetic parameters Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.Targeted Chemotherapy with Metal Complexes.

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P2860

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

http://www.wikidata.org/entity/Q27667351

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Structurally Sophisticated Oct ...... tive Protein Kinase Inhibitors

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Structurally Sophisticated Oct ...... tive Protein Kinase Inhibitors

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Journal of the American Chemical Society

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Structurally Sophisticated Oct ...... tive Protein Kinase Inhibitors

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Alexander Wilbuer

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G Ekin Atilla-Gokcumen

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Gernot Frenking

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Jasna Maksimoska

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Katja Kräling

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Klaus Harms

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Li Feng

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Mehmet Ali Celik

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Sebastian Blanck

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Yann Geisselbrecht

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P2860

Density-functional exchange-energy approximation with correct asymptotic behavior

Finishing the euchromatic sequence of the human genome

Density-functional approximation for the correlation energy of the inhomogeneous electron gas

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors

GSK-3-selective inhibitors derived from Tyrian purple indirubins

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3

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5976-86

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scholarly article

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4770731

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10.1021/JA1112996

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15

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133

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Ronen Marmorstein

Lars-Oliver Essen

Panagis Filippakopoulos

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2011-04-20T00:00:00Z

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50906364

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21446733

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3076536

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