The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2''-Phosphotransferase-IIa [APH(2'')-IIa] Provide Insights into Substrate Selectivity in the APH(2'') Subfamily

The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2''-Phosphotransferase-IIa [APH(2'')-IIa] Provide Insights into Substrate Selectivity in the APH(2'') Subfamily

Item

http://www.wikidata.org/entity/Q27655435

Q27655435

about

Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2″-IVa Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor Aminoglycoside 2′′-Phosphotransferase IIIa (APH(2′′)-IIIa) Prefers GTP over ATP Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation Purification, crystallization and preliminary X-ray analysis of Enterococcus casseliflavus aminoglycoside-2''-phosphotransferase-IVa.Mutant APH(2'')-IIa enzymes with increased activity against amikacin and isepamicin Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.Aminoglycoside modifying enzymes.Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme.Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.Whole-genome sequencing of gentamicin-resistant Campylobacter coli isolated from U.S. retail meats reveals novel plasmid-mediated aminoglycoside resistance genes The antibiotic resistome.Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance.Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase.Effects of altering aminoglycoside structures on bacterial resistance enzyme activities.Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure.In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes.Directed evolution for thermostabilization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2''-phosphotransferase IIa.Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities.

P2860

Q21132445-207CC0DC-C4DE-4ACC-B16E-1F52592CE068 Q26859978-A91FD446-7774-4DB2-8B56-F874C19E28F9 Q27659071-C5225C4B-952C-4EA8-A541-0B1364C68A3E Q27662400-5AD23E57-F121-4BD2-9D2C-B3DFE1B38C8C Q27665944-23480712-252E-4617-83B3-71524855C349 Q27667856-BA1DCDD8-3B62-4F66-92D7-E6776F902946 Q27677499-77C99475-739F-44D3-BF12-6907EB4539BA Q27677520-B1269474-EC49-43A2-81B9-23A30C4A10E3 Q27678586-BE8E1ACB-DEC1-4330-ABF0-09E73D4B3537 Q27684260-A3572DD5-E103-4DAA-84C9-E0D8F4B064C9 Q28543091-23D83F25-832D-4E21-AC8E-B6D0EF748A37 Q30657342-2082E9DE-B841-4DCD-AB1B-45F5640D7C56 Q33586916-72750DDE-C34E-4AA6-9BCC-4D556985BA0E Q33768781-8C6D264D-1C7B-4A8F-81D3-2EC367372E71 Q34299292-013A9D1C-D4BF-4A14-A480-B2D36608883C Q34354185-71D1A50F-F3C8-4715-8EAE-9CF6B3518038 Q36481710-7FF3FA20-92E9-474D-AB1F-9EDD7ECFC70C Q36505481-FAB84772-69A3-487F-92BA-6EE735A1C998 Q37263309-67F4E918-99D7-4D36-B6A9-72A471C58FA8 Q38029141-89309597-B0FD-4FA6-92EA-A5FB8BBD6C0E Q38117380-D72BA09E-3AE2-4C92-8249-6706937A7674 Q40364196-F67FD0D3-925C-455E-BA37-6D3A73BD81A8 Q41838457-ADC524EF-B274-49DB-8E09-AC82284F70B9 Q41885933-B6CF7064-1980-48CF-887D-CD2D76F26F84 Q42215116-2EC54A14-CEAE-4EF8-8366-37DCC12C43F4 Q43019889-2460DDDD-59FA-406A-BE4D-F61970AC89AE Q43079677-EB063F3B-A1C7-47E1-A9C3-51F1335DB34A Q48317932-F5CD47BE-5030-4891-9B9D-233FDECE192F

P2860

The Crystal Structures of Substrate and Nucleotide Complexes of Enterococcus faecium Aminoglycoside-2''-Phosphotransferase-IIa [APH(2'')-IIa] Provide Insights into Substrate Selectivity in the APH(2'') Subfamily

Item

http://www.wikidata.org/entity/Q27655435

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu