Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy
about
RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disordersStructural studies of CNG repeatsTwisting right to left: A…A mismatch in a CAG trinucleotide repeat overexpansion provokes left-handed Z-DNA conformationAtomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseasesNMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1.Crystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndromeA Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X SyndromeUtilizing the GAAA Tetraloop/Receptor To Facilitate Crystal Packing and Determination of the Structure of a CUG RNA HelixMyotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 × 1 Nucleotide UU Internal Loop ConformationsA dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.Crystallographic characterization of CCG repeatsStructural dynamics of double-helical RNAs composed of CUG/CUG- and CUG/CGG-repeatsComputational investigation of RNA CUG repeats responsible for myotonic dystrophy 1Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.Methods to enable the design of bioactive small molecules targeting RNA.Stabilization of RNA hairpins using non-nucleotide linkers and circularization.Oligonucleotide-based strategies to combat polyglutamine diseases.MBNL proteins and their target RNAs, interaction and splicing regulation.Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model.Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1.Selective inhibition of MBNL1-CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2)Triplet repeat RNA structure and its role as pathogenic agent and therapeutic targetStructural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs)RNA Structures as Mediators of Neurological Diseases and as Drug Targets.On the Applicability of Elastic Network Models for the Study of RNA CUG Trinucleotide Repeat Overexpansion.From dynamic combinatorial 'hit' to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy.In silico discovery of substituted pyrido[2,3-d]pyrimidines and pentamidine-like compounds with biological activity in myotonic dystrophy models.Watson-Crick-like pairs in CCUG repeats: evidence for tautomeric shifts or protonation.Investigating the binding mode of an inhibitor of the MBNL1·RNA complex in myotonic dystrophy type 1 (DM1) leads to the unexpected discovery of a DNA-selective binder.The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches--toward anti-sense therapy against TREDsRNA toxicity in polyglutamine disorders: concepts, models, and progress of researchRational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts.MBNL1-RNA recognition: contributions of MBNL1 sequence and RNA conformation.Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions.Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.CAG repeats mimic CUG repeats in the misregulation of alternative splicing.Structures of RNA repeats associated with neurological diseases.Structural diversity of triplet repeat RNAs.Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
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P2860
Structural insights into CUG repeats containing the 'stretched U-U wobble': implications for myotonic dystrophy
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural insights into CUG r ...... cations for myotonic dystrophy
@ast
Structural insights into CUG r ...... cations for myotonic dystrophy
@en
Structural insights into CUG r ...... cations for myotonic dystrophy
@nl
type
label
Structural insights into CUG r ...... cations for myotonic dystrophy
@ast
Structural insights into CUG r ...... cations for myotonic dystrophy
@en
Structural insights into CUG r ...... cations for myotonic dystrophy
@nl
prefLabel
Structural insights into CUG r ...... cations for myotonic dystrophy
@ast
Structural insights into CUG r ...... cations for myotonic dystrophy
@en
Structural insights into CUG r ...... cations for myotonic dystrophy
@nl
P2860
P50
P3181
P356
P1476
Structural insights into CUG r ...... cations for myotonic dystrophy
@en
P2860
P304
P3181
P356
10.1093/NAR/GKP350
P407
P577
2009-07-01T00:00:00Z