Following evolutionary paths to protein-protein interactions with high affinity and selectivity
about
The structural and energetic basis for high selectivity in a high-affinity protein-protein interactionEngineering a model protein cavity to catalyze the Kemp eliminationSomatic hypermutation maintains antibody thermodynamic stability during affinity maturationControl of protein signaling using a computationally designed GTPase/GEF orthogonal pairStructural Basis of a Rationally Rewired Protein-Protein Interface Critical to Bacterial SignalingA new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease: a crystallographic and computational studyDesigning specific protein-protein interactions using computation, experimental library screening, or integrated methodsSequence motifs in MADS transcription factors responsible for specificity and diversification of protein-protein interaction.Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N-terminal mutations.First-step mutations for adaptation at elevated temperature increase capsid stability in a virus.Protein binding specificity versus promiscuity.Biophysics of protein evolution and evolutionary protein biophysicsIntegrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.Intermolecular β-strand networks avoid hub residues and favor low interconnectedness: a potential protection mechanism against chain dissociation upon mutation.InterEvol database: exploring the structure and evolution of protein complex interfaces.Native contact density and nonnative hydrophobic effects in the folding of bacterial immunity proteins.Structures of the Ultra-High-Affinity Protein-Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosaSurface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25.Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants.Structural basis for recognition of the Sec4 Rab GTPase by its effector, the Lgl/tomosyn homologue, Sro7.Structural Perspectives on the Evolutionary Expansion of Unique Protein-Protein Binding Sites.Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders.Diversification of β-Augmentation Interactions between CDI Toxin/Immunity ProteinsCellular crowding imposes global constraints on the chemistry and evolution of proteomes.Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonistNovel Immunity Proteins Associated with Colicin M-like Bacteriocins Exhibit Promiscuous Protection in Pseudomonas.Nuclease colicins and their immunity proteins.Altering the Tat-derived peptide bioactivity landscape by changing the arginine side chain length.Engineering Specificity from Broad to Narrow: Design of a β-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC β-Lactamase.Crucial roles of single residues in binding affinity, specificity, and promiscuity in the cellulosomal cohesin-dockerin interfaceVersatility and invariance in the evolution of homologous heteromeric interfaces.The role of the N-terminal loop in the function of the colicin E7 nuclease domain.Increased Affinity for RNA Targets Evolved Early in Animal and Plant Dicer Lineages through Different Structural Mechanisms.Editorial: Evolution acting on the same target, but at multiple levels: Proteins as the test case.Translocator hunt comes full Cir-Col.
P2860
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P2860
Following evolutionary paths to protein-protein interactions with high affinity and selectivity
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Following evolutionary paths t ...... high affinity and selectivity
@ast
Following evolutionary paths t ...... high affinity and selectivity
@en
Following evolutionary paths t ...... high affinity and selectivity
@nl
type
label
Following evolutionary paths t ...... high affinity and selectivity
@ast
Following evolutionary paths t ...... high affinity and selectivity
@en
Following evolutionary paths t ...... high affinity and selectivity
@nl
prefLabel
Following evolutionary paths t ...... high affinity and selectivity
@ast
Following evolutionary paths t ...... high affinity and selectivity
@en
Following evolutionary paths t ...... high affinity and selectivity
@nl
P2093
P2860
P356
P1476
Following evolutionary paths t ...... high affinity and selectivity
@en
P2093
Anthony H Keeble
Colin Kleanthous
Dan S Tawfik
Kalia Bernath Levin
Shira Albeck
Shlomo Magdassi
P2860
P2888
P304
P356
10.1038/NSMB.1670
P577
2009-10-01T00:00:00Z
P5875
P6179
1029934290