Following evolutionary paths to protein-protein interactions with high affinity and selectivity - Test2 - elhamkhani - TriplyDB

Following evolutionary paths to protein-protein interactions with high affinity and selectivity

Following evolutionary paths to protein-protein interactions with high affinity and selectivity

http://www.wikidata.org/entity/Q27657425

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The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction Engineering a model protein cavity to catalyze the Kemp elimination Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair Structural Basis of a Rationally Rewired Protein-Protein Interface Critical to Bacterial Signaling A new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease: a crystallographic and computational study Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods Sequence motifs in MADS transcription factors responsible for specificity and diversification of protein-protein interaction.Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N-terminal mutations.First-step mutations for adaptation at elevated temperature increase capsid stability in a virus.Protein binding specificity versus promiscuity.Biophysics of protein evolution and evolutionary protein biophysics Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.Intermolecular β-strand networks avoid hub residues and favor low interconnectedness: a potential protection mechanism against chain dissociation upon mutation.InterEvol database: exploring the structure and evolution of protein complex interfaces.Native contact density and nonnative hydrophobic effects in the folding of bacterial immunity proteins.Structures of the Ultra-High-Affinity Protein-Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosa Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25.Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants.Structural basis for recognition of the Sec4 Rab GTPase by its effector, the Lgl/tomosyn homologue, Sro7.Structural Perspectives on the Evolutionary Expansion of Unique Protein-Protein Binding Sites.Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders.Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist Novel Immunity Proteins Associated with Colicin M-like Bacteriocins Exhibit Promiscuous Protection in Pseudomonas.Nuclease colicins and their immunity proteins.Altering the Tat-derived peptide bioactivity landscape by changing the arginine side chain length.Engineering Specificity from Broad to Narrow: Design of a β-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC β-Lactamase.Crucial roles of single residues in binding affinity, specificity, and promiscuity in the cellulosomal cohesin-dockerin interface Versatility and invariance in the evolution of homologous heteromeric interfaces.The role of the N-terminal loop in the function of the colicin E7 nuclease domain.Increased Affinity for RNA Targets Evolved Early in Animal and Plant Dicer Lineages through Different Structural Mechanisms.Editorial: Evolution acting on the same target, but at multiple levels: Proteins as the test case.Translocator hunt comes full Cir-Col.

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P2860

Following evolutionary paths to protein-protein interactions with high affinity and selectivity

http://www.wikidata.org/entity/Q27657425

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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Following evolutionary paths t ...... high affinity and selectivity

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P1433

Nature Structural & Molecular Biology

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Following evolutionary paths t ...... high affinity and selectivity

@en

P2093

Anthony H Keeble

http://www.w3.org/2001/XMLSchema#string

Colin Kleanthous

http://www.w3.org/2001/XMLSchema#string

Dan S Tawfik

http://www.w3.org/2001/XMLSchema#string

Kalia Bernath Levin

http://www.w3.org/2001/XMLSchema#string

Orly Dym

http://www.w3.org/2001/XMLSchema#string

Shira Albeck

http://www.w3.org/2001/XMLSchema#string

Shlomo Magdassi

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P2860

Protein stability promotes evolvability

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

Crystal structure of an ancient protein: evolution by conformational epistasis

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein

Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility

Coot: model-building tools for molecular graphics

Refinement of macromolecular structures by the maximum-likelihood method

P2888

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1049-55

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10.1038/NSMB.1670

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10

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16

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26807840

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1029934290

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19749752

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