Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins
about
Mutations in the pre-replication complex cause Meier-Gorlin syndromePrevention of DNA re-replication in eukaryotic cellsRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityHelicase loading at chromosomal origins of replicationStress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorStructural insights into the Cdt1-mediated MCM2-7 chromatin loading.Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicasesCharacterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.Mechanisms and regulation of DNA replication initiation in eukaryotes.Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.From structure to mechanism-understanding initiation of DNA replication.Cdt1 stabilizes an open MCM ring for helicase loading.Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer.The Temporal Regulation of S Phase Proteins During G1.
P2860
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P2860
Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins
description
2010 nî lūn-bûn
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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
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2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@ast
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@en
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@nl
type
label
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@ast
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@en
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@nl
prefLabel
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@ast
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@en
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@nl
P2093
P2860
P50
P356
P1476
Structure and mutagenesis stud ...... licative helicase Mcm proteins
@en
P2093
Fumio Hanaoka
Gentaro Yasuda
Jungoo Jee
Ken-Ichiro Yanagi
Masahiro Shirakawa
Takeshi Mizuno
Yasumasa Chiba
P2860
P304
15931-15940
P356
10.1074/JBC.M109.075333
P407
P577
2010-03-24T00:00:00Z