Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

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http://www.wikidata.org/entity/Q27660318
Mutations in the pre-replication complex cause Meier-Gorlin syndromePrevention of DNA re-replication in eukaryotic cellsRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityHelicase loading at chromosomal origins of replicationStress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorStructural insights into the Cdt1-mediated MCM2-7 chromatin loading.Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicasesCharacterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.Mechanisms and regulation of DNA replication initiation in eukaryotes.Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.From structure to mechanism-understanding initiation of DNA replication.Cdt1 stabilizes an open MCM ring for helicase loading.Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer.The Temporal Regulation of S Phase Proteins During G1.
P2860

Structure and Mutagenesis Studies of the C-terminal Region of Licensing Factor Cdt1 Enable the Identification of Key Residues for Binding to Replicative Helicase Mcm Proteins

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http://www.wikidata.org/entity/Q27660318
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2010 nî lūn-bûn
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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2010 թվականի մայիսին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@ast
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@en
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
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label
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
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Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
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Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@nl
prefLabel
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@ast
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@en
Structure and Mutagenesis Stud ...... licative Helicase Mcm Proteins
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
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P1433
P1476
Structure and mutagenesis stud ...... licative helicase Mcm proteins
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932