Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module - Test2 - elhamkhani - TriplyDB

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

http://www.wikidata.org/entity/Q27660560

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A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties Ubiquitin-specific peptidase 22 functions and its involvement in disease The structure of human ubiquitin in 2-methyl-2,4-pentanediol: A new conformational switch A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20 Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6-Bre1 Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module Transplanting supersites of HIV-1 vulnerability.Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7.Sus1p facilitates pre-initiation complex formation at the SAGA-regulated genes independently of histone H2B de-ubiquitylation The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.Multiple functions of BCL-2 family proteins.The role of deubiquitinating enzymes in chromatin regulation.The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.SUS1 introns are required for efficient mRNA nuclear export in yeast Conformational flexibility and subunit arrangement of the modular yeast Spt-Ada-Gcn5 acetyltransferase complex Splitting the task: Ubp8 and Ubp10 deubiquitinate different cellular pools of H2BK123.Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development Drosophila models reveal novel insights into mechanisms underlying neurodegeneration.Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity.Using protein motion to read, write, and erase ubiquitin signals.Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling.SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4.Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae.Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells.Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.

P2860

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P2860

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

http://www.wikidata.org/entity/Q27660560

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@ast

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@en

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@nl

type

label

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@ast

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@en

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@nl

prefLabel

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@ast

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@en

Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

@nl

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SCIENCE.1190049

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Structural insights into the assembly and function of the SAGA deubiquitinating module

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Ajit B Datta

http://www.w3.org/2001/XMLSchema#string

Nadine L Samara

http://www.w3.org/2001/XMLSchema#string

Robert E Cohen

http://www.w3.org/2001/XMLSchema#string

Tingting Yao

http://www.w3.org/2001/XMLSchema#string

Xiangbin Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

The expression patterns of deubiquitinating enzymes, USP22 and Usp22

The solution structure of the ZnF UBP domain of USP33/VDU1

Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.

Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export

The deubiquitylation activity of Ubp8 is dependent upon Sgf11 and its association with the SAGA complex.

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.

Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes.

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1025-1029

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scholarly article

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1338665

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10.1126/SCIENCE.1190049

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5981

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328

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Christopher E. Berndsen

Cynthia Wolberger

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2010-04-15T00:00:00Z

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20395473

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4220450

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