A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
about
Ubiquitin-specific peptidase 22 functions and its involvement in diseaseUSP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway.The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock.A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species.Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.Functions of SAGA in development and disease.Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation.The Cellular Protein Complex Associated with a Transforming Region of E1A Contains c-MYC.LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2).Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides.Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer.The evolutionarily conserved factor Sus1/ENY2 plays a role in telomere length maintenance.High expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis.
P2860
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
P248
Q26750743-184ED442-09CA-4DA4-8D5A-099D3B7317D7Q33787348-16029862-7CC0-48B1-A2D0-F0448F63E03AQ34235677-3BF42BC9-9B02-45E9-B9BA-1D15E8EE5355Q34824438-FF001105-A90F-44A8-848B-6450C511B3ADQ35009327-53F7DE8D-9EFF-4933-8731-1F0C4298BB19Q36185343-69781316-384B-43C3-A810-DD5563AD2FB7Q36321255-9491E564-F995-436B-BFC5-6D85FE9713BCQ37224993-BE721894-2179-4378-8A5F-D2075B447E91Q37417990-D4082710-CEFD-4D98-9E46-6FFAE62405ECQ37541596-7FED7832-0E2B-42B2-90CD-FCCB0A53C714Q38238829-89D3239D-6ABC-4087-A702-0ACE974ED0DAQ38698832-0AF5C6A4-6582-423F-889A-9791640A1DFAQ38758681-5FB8192F-D78E-428D-82D8-9E4361ED0B3AQ38820113-EB741A11-D3E6-4F41-8340-6BC00D3FD7EFQ38976444-39706B10-FF9F-4AA7-8FBE-1840EAD55BA8Q38989377-66E18448-F402-4AAC-B6F7-BBEFD817C520Q39140357-185A6E4F-9079-4252-A004-15AC899BC1B4Q39559509-0AF8C5CE-F282-4FAA-9DB8-6E6DF25DFBCAQ41701390-2EB22B3D-C888-4970-BFDF-4A7F05E2D17EQ47359149-CF55DDF3-D59B-4D64-8C55-50FDC43E3795Q47425675-C43705C4-D112-4848-92AD-F4286156FBCDQ55387283-B2ADF71F-7DC1-4D7D-961C-EF811114B34E
P2860
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A high-confidence interaction ...... d the SAGA coactivator complex
@ast
A high-confidence interaction ...... d the SAGA coactivator complex
@en
A high-confidence interaction ...... d the SAGA coactivator complex
@en-gb
A high-confidence interaction ...... d the SAGA coactivator complex
@nl
type
label
A high-confidence interaction ...... d the SAGA coactivator complex
@ast
A high-confidence interaction ...... d the SAGA coactivator complex
@en
A high-confidence interaction ...... d the SAGA coactivator complex
@en-gb
A high-confidence interaction ...... d the SAGA coactivator complex
@nl
prefLabel
A high-confidence interaction ...... d the SAGA coactivator complex
@ast
A high-confidence interaction ...... d the SAGA coactivator complex
@en
A high-confidence interaction ...... d the SAGA coactivator complex
@en-gb
A high-confidence interaction ...... d the SAGA coactivator complex
@nl
P2093
P2860
P50
P3181
P356
P1476
A high-confidence interaction ...... d the SAGA coactivator complex
@en
P2093
Craig R Braun
Eric J Bennett
Sean M Armour
Steven B McMahon
Xiao-Yong Zhang
P2860
P304
P3181
P356
10.1128/MCB.00971-12
P407
P577
2013-02-04T00:00:00Z